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Comprehensive lipid profiling and metabolic pathway analysis of Ocimum: Unveiling key variations and regulatory mechanisms for breeding and metabolic exploration

文献类型： 外文期刊

作者： Yang, Jingtian 1 ; Zhang, Chengting 3 ; Yu, Mengling 1 ; Yuan, Jing 1 ; Mao, Yanping 4 ; Liu, Mei 1 ; Liu, Lei 4 ; Guan, Lingliang 2 ;

作者机构： 1.Mianyang Normal Univ, Ecol Secur & Protect Key Lab Sichuan Prov, Mianyang, Peoples R China

2.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Haikou, Peoples R China

3.Beichuan Qiang Autonomous Cty Agr & Rural Bur, Mianyang, Peoples R China

4.Mianyang Normal Univ, Coll Life Sci & Biotechnol, Mianyang, Peoples R China

关键词： Ocimum; Lipid metabolomics; Free fatty acids; Linoleic acid; Regulatory network

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）

ISSN： 2212-4292

年卷期： 2025 年 66 卷

页码：

收录情况： SCI

摘要： Lipids play a pivotal role in metabolic research and have garnered significant interest in biological endeavors. Ocimum is a plant of significant medicinal and edible value. However, it remains an underexplored frontier in lipid metabolism research. We employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to comprehensively profile the lipid metabolites in six distinct Ocimum accessions. Additionally, transcriptome sequencing was utilized to analyze genes associated with metabolic pathways. A total of 191 lipid metabolites across these accessions were identified, categorized into six classes, with free fatty acids being the most abundant. Among these, 153 lipid metabolites exhibited differential accumulation across the accessions, highlighting key variations. Intraspecific differences in these lipid metabolites were minimal, whereas interspecific differences were pronounced. Notably, accession G072 (Ocimum x Africanum) was distinguished for its high accumulation of differential lipid metabolites, underscoring its significance for further exploration. Subsequent weighted gene co-expression network analysis (WGCNA) pinpointed 28 candidate genes with differential expression, which, together with six candidate differential lipid metabolites, were used to construct a regulatory network. Our research has identified linoleic acid as the predominant differential lipid metabolite in Ocimum, with the LOX (lipoxygenase) gene potentially being the most influential factor in modulating the levels of linoleic acid. This study establishes a crucial foundation for the in-depth investigation of Ocimum lipid metabolism, offering valuable insights for selecting innovative germplasm and providing a reference for the comprehensive development and utilization of Ocimum species.

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