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Integrated multifunctional liquid metal enhanced hydrogel system for chronic infected wound with sinus tract treatment and monitoring

文献类型： 外文期刊

作者： Ruan, Chengxin 1 ; Zhao, Jinxue 2 ; Jin, Jiale 1 ; Li, Dongdong 4 ; Wang, Dongyu 1 ; Luo, Zhiyuan 1 ; Li, Peiyi 2 ; Sinha, Apoorva 5 ; Ong, Tim-yun Michael 6 ; Wu, Lidong 2 ; Lei, Pengfei 1 ;

作者机构： 1.Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Orthoped Surg, Hangzhou 310003, Peoples R China

2.Chinese Acad Fishery Sci, Beijing 100141, Peoples R China

3.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China

4.Ningxia Med Univ, Sch Clin Med 1, Yinchuan 750000, Peoples R China

5.Zhejiang Univ, Sch Med, Hangzhou 310003, Peoples R China

6.Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China

关键词： (Chronic infected wounds; Multifunctional system; Bioelectronics; Liquid metals)

期刊名称：CHEMICAL ENGINEERING JOURNAL （ 影响因子：13.2； 五年影响因子：13.5 ）

ISSN： 1385-8947

年卷期： 2025 年 519 卷

页码：

收录情况： SCI

摘要： Chronic infected wounds, such as sinus tracts, pose a global challenge, adding to the significant socioeconomic burden of healthcare systems. Existing wound repair materials struggle to meet the complex needs of chronic wound healing. This study developed a mussel-inspired, liquid metal (LM)-enhanced composite hydrogel system (PDA-LM) that simultaneously meets the challenging requirements of treating and monitoring chronic infection wounds. This composite hydrogel offers superior adhesion, antibacterial activity, and proangiogenic effects, altogether promoting early wound closure, controlling bleeding, inhibiting infection, and accelerating healing. In addition, it possesses exceptional sensing capabilities, capable of real-time monitoring of physiological data such as respiration, electrocardiogram (ECG), and electromyogram (EMG) to assist in wound management. This work underscores the significance of multifunctional electronic hydrogels in chronic wound care and offers new insights into the design of the next generation of integrated wound treatment solutions.

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