文献类型： 外文期刊
作者： Zhang, Tao 1 ; Xu, Shuang-yan 1 ; Lin, Hui 2 ; Yang, Jian 1 ; Zhao, Zhuo-qun 1 ; Barcelo, Damia 3 ; Zheng, Hua-bao 1 ;
作者机构： 1.Zhejiang A&F Univ, Key Lab Soil Contaminat Bioremediat Zhejiang Prov, Coll Environm & Resources Sci, Hangzhou 311300, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Environm Resources Soil & Fertilizes, Hangzhou 310021, Peoples R China
3.Univ Girona, Catalan Inst Water Res ICRA, Sci & Technol Pk, Girona 17003, Spain
关键词： Tylosin; Klebsiella oxytoca; Degradation pathway; Transcriptome analysis; Antibiotic resistance genes
期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：10.753； 五年影响因子：10.237 ）
ISSN： 0048-9697
年卷期： 2022 年 847 卷
页码：
收录情况： SCI
摘要： Tylosin is widely used in livestock; however, the release of tylosin through animal manure can cause serious environ-mental problems. In this study, a new tylosin-degrading strain, TYL-T1, was isolated. Its phylogenetic similarity to Klebsiella oxytoca was found to be 99.17 %. TYL-T1 maintained good growth at 40 degrees C over a broad pH range (4.0-10 ). TYL-T1 degraded 99.34 % of tylosin in 36 h under optimal conditions (tylosin initial concentration: 25 mg/L, pH: 7.0, and temperature: 35 degrees C). After LC-MS-MS analysis, a new degradation pathway for tylosin was pro-posed, including ester bond breaking of the macrolide lactone ring, redox reaction, and loss of mycinose and mycarose. Based on a transcriptome analysis, 164 genes essential for degradation were upregulated through hydrolysis and redox of tylosin. Among various transferases, lipopolysaccharide methyltransferase, glycogen glucosyltransferase, and fructotransferase were responsible for tylosin degradation. The present study revealed the degradation mechanism of tylosin and highlighted the potential of Klebsiella oxytoca TYL-T1 to remove tylosin from the environment.
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