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Transcriptome analysis reveals that high temperatures alter modes of lipid metabolism in juvenile turbot (Scophthalmus maximus) liver

文献类型： 外文期刊

作者： Zhao, Tingting 1 ; Ma, Aijun 1 ; Huang, Zhihui 1 ; Liu, Zhifeng 1 ; Sun, Zhibin 1 ; Zhu, Chunyue 1 ; Yang, Jingkun 1 ; Li 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China

3.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Minist Educ, Shanghai 201306, Peoples R China

4.Weihai Zhongfu Aquaculture Co Ltd, Weihai 264329, Peoples R China

5.Shandong Key Lab Marine Fisheries Biotechnol & Ge, Qingdao 266071, Peoples R China

6.Qingdao Key Lab Marine Fish Breeding & Biotechnol, Qingdao 266071, Peoples R China

关键词： Scophthalmus maximus; High temperature; Lipid metabolism; RNA-seq

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS （ 影响因子：2.674； 五年影响因子：2.941 ）

ISSN： 1744-117X

年卷期： 2021 年 40 卷

页码：

收录情况： SCI

摘要： With the increase in farming density and the continuously high summer temperatures against the background of global warming, high temperature stress has become a major challenge in fish farming. In this study, we simulated the high temperature environments (20 degrees C, 24 degrees C, and 28 degrees C) that may occur during turbot culture. High-throughput sequencing was used to investigate the lipid metabolism response patterns in juvenile turbot liver under high temperature stress. A total of 2067 differentially expressed genes (DEGs) were identified. KEGG analysis revealed that the DEGs were mainly associated with glycerophospholipid metabolism, steroid biosynthesis, glycerolipid metabolism, fatty acid metabolic pathways, and the PPAR signaling pathway. A regulatory network was constructed to further elucidate the transcriptional regulation of lipid metabolism. We speculated that high temperature activates PPAR signaling pathway through interaction with ligands such as fatty acids. On the one hand, the HMGCS1 gene in this pathway can inhibit sterol synthesis by down-regulating the expression of key genes in steroid biosynthesis pathway (SQLE, EBP, and DHCR24). On the other hand, the expression of ACSL1 in this pathway is significantly increased under high temperature, which may play an important role in regulating fatty acid metabolism. Moreover, we collected blood and detected changes in serum lipid parameters; the variation patterns were also consistent with our results. These findings reveal that lipid metabolism has an important regulatory role in stress resistance when turbot is exposed to high temperatures.

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