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Zinc alters behavioral phenotypes, neurotransmitter signatures, and immune homeostasis in male zebrafish (Danio rerio)

文献类型： 外文期刊

作者： Yu, Fan 1 ; Hou, Zhi-Shuai 2 ; Luo, Hong-Rui 1 ; Cui, Xue-Fan 5 ; Xiao, Jun 6 ; Kim, Young-Bum 3 ; Li, Jian-Lin 1 ; Feng, Wen-Rong 1 ; Tang, Yong-Kai 1 ; Li, Hong-Xia 1 ; Su, Sheng-Yan 1 ; Song, Chang-You 1 ; Wang, Mei-Yao 1 ; Xu, Pao 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resource, Minist Agr, Wuxi 214081, Jiangsu, Peoples R China

2.Ocean Univ China, Key Lab Mariculture, Minist Educ KLMME, Qingdao 266003, Peoples R China

3.Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

4.Harvard Med Sch, Boston, MA 02215 USA

5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

6.Guangxi Acad Fishery Sci, Guangxi Key Lab Aquat Genet Breeding & Hlth Aquac, Nanning 530021, Peoples R China

关键词： Danio rerio; Zinc exposure; Behavior; Physiology; Neurotransmitter; Immunomodulation

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：10.753； 五年影响因子：10.237 ）

ISSN： 0048-9697

年卷期： 2022 年 828 卷

页码：

收录情况： SCI

摘要： Anthropogenic activities discharge zinc into aquatic ecosystems, and the effects of long-term and low-concentration zinc exposure on fish behavior are unclear. We evaluated the behavior and physiology of male zebrafish (Danio rerio) after a 6-week exposure to 1.0 or 1.5 ppm (mg/L) zinc chloride. The exposure caused anxiety-like behaviors and altered the social preferences in both exposure groups. Analysis of transcriptional changes suggested that in the brain, zinc exerted heterogenetic effects on immune and neurotransmitter functions. Exposure to 1.0 ppm zinc chloride resulted in constitutive immune dyshomeostasis, while exposure to 1.5 ppm zinc chloride impaired the neurotransmitter glutamate. In the intestine, zinc dysregulated self-renewal of intestinal cells, a potential loss of defense function. Moreover, exposure to 1.5 ppm zinc chloride suppressed intestinal immune functions and dysregulated tyrosine metabolism. These behavioral alterations suggested that the underlying mechanisms were distinct and concentration-specific. Overall, environmental levels of zinc can alter male zebrafish behaviors by dysregulating neurotransmitter and immunomodulation signatures.

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