Zinc alters behavioral phenotypes, neurotransmitter signatures, and immune homeostasis in male zebrafish (Danio rerio)
文献类型： 外文期刊
作者： Yu, Fan 1 ; Hou, Zhi-Shuai 2 ; Luo, Hong-Rui 1 ; Cui, Xue-Fan 5 ; Xiao, Jun 6 ; Kim, Young-Bum 3 ; Li, Jian-Lin 1 ; Feng, Wen-Rong 1 ; Tang, Yong-Kai 1 ; Li, Hong-Xia 1 ; Su, Sheng-Yan 1 ; Song, Chang-You 1 ; Wang, Mei-Yao 1 ; Xu, Pao 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resource, Minist Agr, Wuxi 214081, Jiangsu, Peoples R China
2.Ocean Univ China, Key Lab Mariculture, Minist Educ KLMME, Qingdao 266003, Peoples R China
3.Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA
4.Harvard Med Sch, Boston, MA 02215 USA
5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
6.Guangxi Acad Fishery Sci, Guangxi Key Lab Aquat Genet Breeding & Hlth Aquac, Nanning 530021, Peoples R China
关键词： Danio rerio; Zinc exposure; Behavior; Physiology; Neurotransmitter; Immunomodulation
期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：10.753； 五年影响因子：10.237 ）
ISSN： 0048-9697
年卷期： 2022 年 828 卷
页码：
收录情况： SCI
摘要： Anthropogenic activities discharge zinc into aquatic ecosystems, and the effects of long-term and low-concentration zinc exposure on fish behavior are unclear. We evaluated the behavior and physiology of male zebrafish (Danio rerio) after a 6-week exposure to 1.0 or 1.5 ppm (mg/L) zinc chloride. The exposure caused anxiety-like behaviors and altered the social preferences in both exposure groups. Analysis of transcriptional changes suggested that in the brain, zinc exerted heterogenetic effects on immune and neurotransmitter functions. Exposure to 1.0 ppm zinc chloride resulted in constitutive immune dyshomeostasis, while exposure to 1.5 ppm zinc chloride impaired the neurotransmitter glutamate. In the intestine, zinc dysregulated self-renewal of intestinal cells, a potential loss of defense function. Moreover, exposure to 1.5 ppm zinc chloride suppressed intestinal immune functions and dysregulated tyrosine metabolism. These behavioral alterations suggested that the underlying mechanisms were distinct and concentration-specific. Overall, environmental levels of zinc can alter male zebrafish behaviors by dysregulating neurotransmitter and immunomodulation signatures.
- 相关文献
作者其他论文 更多>>
-
Effects of selenium on the growth and immune gene functions of red swamp crayfish (Procambarus clakii)
作者：Sumana, Sahr Lamin;Yu, Fan;Ming, Chen;Minli, Zhu;Muhammad, Abdullateef Mukhtar;Chrstiana, Falayi Opeoluwa;Su, Shengyan;Wang, Peipei;Huang, Cailin;Liao, Yu;Zhang, Zhixin;Cao, Shouxiong;Su, Shengyan
关键词：Selenium; Soils; Crayfish muscles; Transcriptome; Antioxidant activities
-
Multi-omics and biochemical analyses provide insights into hepatic glucolipid metabolism in red tilapia ( Oreochromis spp.) under salinity stress
作者：Jiang, Bingjie;Tao, Yifan;Lu, Siqi;Hua, Jixiang;Li, Yan;Dong, Yalun;Xu, Pao;Qiang, Jun;Huang, Renshan;Xu, Pao;Qiang, Jun
关键词：Glucolipid metabolism; Multi-omics; Physiological response; Red tilapia; Salinity stress
-
Genome-Wide Association Study and RNA-Seq Analysis Uncover Candidate Genes Controlling Growth Traits in Red Tilapia (Oreochromis spp.) Under Hyperosmotic Stress
作者：Jiang, Bingjie;Tao, Yifan;Lu, Siqi;Xu, Pao;Qiang, Jun;Liu, Kai;Tao, Wenjing;Badran, Mohamed Fekri;Saleh, Moustafa Hassan Lotfy;Aboueleila, Rahma Halim Mahmoud;Xu, Pao;Qiang, Jun;Liu, Kai
关键词：red tilapia; growth traits; RNA-seq; GWAS; candidate gene
-
Immune response of intestinal micrornas to transport stress in hybrid yellow catfish (tachysurus fulvidraco♀ xt. vachellii♂) : response strategy and potential biomarker
作者：Zheng, Tao;Zheng, Tao;Qiang, Jun;Xu, Pao;Zheng, Tao;Tao, Yifan;Lu, Siqi;Qiang, Jun;Xu, Pao
关键词：Transport stress; Intestine; Immune regulation; Hybrid yellow catfish; RNA sequencing
-
Gut Microbe Rikenellaceae_RC9_gut_group and Knoellia-Mediated Acetic Acid Regulates Glucose and Lipid Metabolism in the Muscle of Freshwater Drum (Aplodinotus grunniens) Under High-Fat Diets
作者：Xue, Miaomiao;Xu, Pao;Wen, Haibo;Chen, Jianxiang;Kong, Changxin;Li, Xiaowei;Wang, Hang;Guo, Xinxin;Su, Yi;Li, Hongxia;Song, Changyou;Xu, Pao;Wen, Haibo;He, Jiyan;Chen, Jianxiang;Li, Hongxia;Song, Changyou
关键词：acetic acid;
Aplodinotus grunniens ; glycolipid metabolism; gut microbes; high-fat diet; muscle -
Intestinal Microbiota and Gene Expression Alterations in Chinese Mitten Crab (Eriocheir sinensis) Under Deltamethrin Exposure
作者：Zhong, Chunyi;Du, Jinliang;Xu, Gangchun;Xu, Pao;Zhong, Chunyi;Du, Jinliang;Zhu, Haojun;Gao, Jiancao;Xu, Gangchun;Xu, Pao;Du, Jinliang
关键词：Chinese mitten crab (Eriocheir sinensis); intestinal tissue; deltamethrin; oxidative stress; intestinal microbiome
-
Rice-fish co-culture improves carp (Cyprinus carpio) quality by modulating the gut microbiota and metabolites
作者：Nie, Zhijuan;Xu, Xiaotong;Ji, Yanhan;Gao, Ping;Zhou, Sihan;He, Jian;Liu, Xu;Wang, Baozhan;Nie, Zhijuan;Sun, Yi;Wang, Lanmei;Shao, Nailing;Xu, Pao;Shi, Yu
关键词：Rice-fish co-culture; Gut microbiome; Community assembly; Network analysis
