Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm
文献类型： 外文期刊
作者： Ding, Xian 1 ; Yin, Bo 3 ; Qian, Li 4 ; Zeng, Zhirui 1 ; Yang, Zeliang 1 ; Li, Huixian 1 ; Lu, Yongjun 1 ; Zhou, Shining 1 ;
作者机构： 1.Zhongshan Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China
2.Chinese Acad Fishery Sci, S China Sea Fisheries Res Inst, Guangzhou 510300, Guangdong, Peoples R China
3.Chinese Acad Sci, S China Sea Inst Oceanol, LED, Guangzhou 510301, Guangdong, Peoples R China
4.Zhongshan Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
期刊名称：JOURNAL OF MEDICAL MICROBIOLOGY （ 影响因子：2.472； 五年影响因子：2.836 ）
ISSN： 0022-2615
年卷期： 2011 年 60 卷 12 期
页码：
收录情况： SCI
摘要： The objective of this study was to screen for novel quorum-sensing inhibitors (QSIs) from traditional Chinese medicines (TCMs) that inhibit bacterial biofilm formation. Six of 46 active components found in TCMs were identified as putative OS's based on molecular docking studies. Of these, three compounds inhibited biofilm formation by Pseudomonas aeruginosa and Stenotrophomonas maltophilia at a concentration of 200 mu M. A fourth compound (emodin) significantly inhibited biofilm formation at 20 mu M and induced proteolysis of the quorum-sensing signal receptor TraR in Escherichia coli at a concentration of 3-30 mM. Emodin also increased the activity of ampicillin against P. aeruginosa. Therefore, emodin might be suitable for development into an antivirulence and antibacterial agent.
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