中国水产科学研究院机构知识库

Isolation of a polysaccharide with antiproliferative, hypoglycemic, antioxidant and HIV-1 reverse transcriptase inhibitory activities from the fruiting bodies of the abalone mushroom Pleurotus abalonus

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文献类型：外文期刊

作者： Wang, Chang Rong ² ; Tzi Bun Ng ¹ ; Li, Le ³ ; Fang, Jin Cen ³ ; Jiang, Yun ² ; Wen, Ting Yi ⁴ ; Qiao, Wen Tao ² ; Li, Ni ¹ ;

作者机构： 1.Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Shatin, Hong Kong, Peoples R China

2.Nankai Univ, Dept Microbiol, Ctr AIDS Res, Tianjin 300071, Peoples R China

3.Chinese Acad Fishery Sci, Res Ctr Fishery Prod Standard & Qual, Beijing, Peoples R China

4.Chinese Acad Sci, Key Lab Syst Microbial Biotechnol, Inst Microbiol, Beijing, Peoples R China

关键词： antioxidant;antiproliferative;Pleurotus abalonus;polysaccharide

期刊名称：JOURNAL OF PHARMACY AND PHARMACOLOGY （影响因子：3.765；五年影响因子：3.546 ）

ISSN： 0022-3573

年卷期： 2011 年 63 卷 6 期

页码：

收录情况： SCI

摘要： Objective The intent of this study was to purify and characterize a polysaccharide named LA from the fruiting bodies of the edible mushroom Pleurotus abalones. Methods The 120-kDa polysaccharide was obtained by extraction with boiling water, ethanol precipitation, ion exchange chromatography on Diethylaminoethyl-cellulose and gel filtration on Sephadex G-200. Key findings The LA was composed of glucose, rhamnose, glucuronic acid, xylose, galactose and arabinose in the molar ratio of 26.3 : 2.7 : 1 : 1.4 : 1.8 : 1.2. The FITR and 1H-NMR spectrum of LA disclosed that it was a saccharide with an alpha-configuration. Its 13C-NMR spectrum revealed that its main chain was [-> 6)-alpha-d-Gly(1 ->](n). The LA exhibited antioxidant activities, especially in scavenging 1,1- diphenyl-2-picryl-hydrazyl radicals and hydroxyl radicals. It manifested antiproliferative activity towards breast cancer MCF7 cells with an IC50 of 3.7 mu m, and also exerted some antiproliferative activity against HepG2 cells. It manifested a hypoglycemic action on diabetic mice. It inhibited HIV-1 reverse transcriptase with an IC50 of 8.7 x 10-2 mu m. Conclusions The polysaccharide from the abalone mushroom.

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