Polysaccharides affect the utilization of 8-carotene through gut microbiota investigated by in vitro and in vivo experiments
文献类型： 外文期刊
作者： Shi, Enjuan 1 ; Nie, Meimei 1 ; Wang, Xiaoqin 1 ; Jing, Huili 1 ; Feng, Lei 1 ; Xu, Yayuan 1 ; Zhang, Zhongyuan 1 ; Zhang, Guodong 3 ; Li, Dajing 1 ; Dai, Zhuqing 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China
2.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China
3.Jiangsu Aland Nutr Co Ltd, Taizhou 214500, Peoples R China
关键词： 8-carotene; Polysaccharides; Retinoids; Utilization; Gut microbiota
期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.1； 五年影响因子：7.7 ）
ISSN： 0963-9969
年卷期： 2023 年 174 卷
页码：
收录情况： SCI
摘要： This study aimed to evaluate the effects of six polysaccharides on the utilization of 8-carotene from the perspective of gut microbiota using both in vitro simulated anaerobic fermentation systems and in vivo animal experiments. In the in vitro experiments, the addition of arabinoxylan, arabinogalactan, mannan, inulin, chitosan, and glucan led to a 31.07-79.12% decrease in 8-carotene retention and a significant increase in retinol content (0.21-0.99-fold) compared to 8-carotene alone. Among them, the addition of chitosan produced the highest level of retinol. In the in vivo experiments, mice treated with the six polysaccharides exhibited a significant increase (2.51-5.78-fold) in serum 8-carotene content compared to the group treated with 8-carotene alone. The accumulation of retinoids in the serum, liver, and small intestine increased by 13.56-21.61%, 12.64-56.27%, and 7.9%-71.69%, respectively. The expression of 8-carotene cleavage enzymes was increased in the liver. Genetic analysis of small intestinal tissue revealed no significant enhancement in the expression of genes related to 8-carotene metabolism. In the gut microbiota environment, the addition of polysaccharides generated more SCFAs and altered the structure and composition of the gut microbiota. The correlation analysis revealed a strong association between gut microbes (Ruminococcaceae and Odoribacteraceae) and 8-carotene metabolism and absorption. Collectively, our findings suggest that the addition of polysaccharides may improve 8-carotene utilization by modulating the gut microbiota.
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