A facile synthesis of Cu(II) diethyldithiocarbamate from monovalent copper-cysteamine and disulfiram
文献类型： 外文期刊
作者： Wang, Lingyun 1 ; Chen, Zeliang 1 ; Ran, Xueguang 2 ; Tang, Hao 1 ; Cao, Derong 1 ;
作者机构： 1.South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, 381 Wushan Rd, Guangzhou 510641, Peoples R China
2.Guangdong Acad Agr Sci, Inst Anim Sci, Key Lab Anim Nutr & Feed Sci South Chi, State Key Lab Livestock & Poultry Breeding,Minist, Guangzhou 510641, Peoples R China
关键词： Copper(II) diethyldithiocarbamate (Cu(DDC)(2)); Disulfiram (DSF); Copper(I) cysteamine (Cu(I)Cy); Synthesis; Photolysis
期刊名称：INORGANIC CHEMISTRY COMMUNICATIONS （ 影响因子：3.428； 五年影响因子：2.553 ）
ISSN： 1387-7003
年卷期： 2022 年 137 卷
页码：
收录情况： SCI
摘要： The copper(II) diethyldithiocarbamate (Cu(DDC)(2)) complex prepared from disulfiram and Cu(II) species has shown excellent anticancer activity. However, general synthetic methods largely rely on tedious procedures and limited reaction types with undesirable by-products. In this paper, we reported an efficient and atom-economic synthesis of Cu(DDC)(2) from disulfiram and monovalent copper cysteamine (Cu(I)Cy) via a one-step oxidation-reduction reaction. Cu(DDC)(2) was fully characterized by nuclear magnetic resonance (NMR), mass spectrometry (MS), infrared spectroscopy (IR), scanning electron microscope (SEM), X-ray diffraction (XRD), ultraviolet and visible (UV-Vis) spectrophotometry, X-ray photoelectron spectroscopy (XPS), electron paramagnetic resonance (EPR) and single crystal X-ray diffraction. The proposed reaction mechanism and the effect of reaction conditions on the Cu(DDC)(2) synthesis were investigated. The photochemical reactions of Cu(DDC)(2) was studied in acetone, DMF, toluene, CCl4, CHCl3 under 254, 365 nm alone or combined 254 & 365 nm irradiation based on UV-vis and EPR measurements. The photolysis rate followed in this order: CCl4 > CHCl3 > DMF > toluene > acetone. The final photolysis products in CHCl3 were DSF and Cu-2(DDC)(2)Cl-2.
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