Genomic analysis of hypoxia-tolerant population of the Chinese mitten crab (Eriocheir sinensis)
文献类型： 外文期刊
作者： Yan, Feng-yuan 1 ; Xu, Yuan-feng 2 ; Feng, Wen-rong 2 ; He, Qing-hong 1 ; Hua, Guo-an 3 ; Li, Wen-jing 3 ; Xu, Pao 2 ; Zhou, Jun 4 ; Tang, Yong-kai 1 ;
作者机构： 1.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai 201306, Peoples R China
2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resources, Minist Agr & Rural Affairs, Wuxi 214081, Peoples R China
3.Jiangsu Haorun Biol Ind Grp Co Ltd, Taizhou 225500, Peoples R China
4.Freshwater Fisheries Res Inst Jiangsu Prov, Nanjing 210017, Peoples R China
关键词： Hypoxic; SNPs; GWAS
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：3.9； 五年影响因子：4.2 ）
ISSN： 1050-4648
年卷期： 2024 年 154 卷
页码：
收录情况： SCI
摘要： Hypoxic stress, triggered by a multitude of factors, has inflicted significant economic repercussions on the aquaculture of Eriocheir sinensis. In this research, we sequenced a collective of 60 samples from both hypoxiasensitive and hypoxia-resistant groups utilizing streamlined genome sequencing techniques. Subsequently, we delved into population evolution, scrutinized the selective sweep within these populations, and performed a genome-wide association study (GWAS) focused on the hypoxia tolerance traits within the population, all through the lens of SNPs molecular markers. This comprehensive analysis aimed to uncover the SNPs and pinpoint the pertinent candidate genes that influence the hypoxia tolerance capabilities of E. sinensis. The selective sweep analysis revealed that genes harboring potential genetic variations within the two populations were predominantly enriched in areas such as signaling molecules and interactions, energy metabolism, glycolipid metabolism, and immune response. In the genome-wide association study focusing on hypoxia tolerance traits, we identified four SNPs significantly associated with hypoxia resistance. Furthermore, one potential candidate gene, Dscam2, which is believed to influence hypoxia tolerance, was discovered within a 50 kb vicinity of these SNPs. These identified SNPs can serve as molecular markers for screening hypoxia tolerance, offering valuable insights for the genetic improvement of E. sinensis.
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