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Single-step genome-wide association study reveals candidate genes for body mass index trait in Yunong-black pigs

文献类型： 外文期刊

作者： Wu, Ziyi 1 ; Dou, Tengfei 1 ; Wu, Jiahao 1 ; Bai, Liyao 1 ; Zhang, Yongqian 2 ; Zan, Shengyuan 2 ; Yang, Songbai 2 ; Zhou, Hao 1 ; Han, Jinyi 1 ; Han, Xuelei 1 ; Qiao, Ruimin 1 ; Wang, Kejun 1 ; Yang, Feng 1 ; Li, Xin-Jian 1 ; Li, Xiu-Ling 1 ;

作者机构： 1.Henan Agr Univ, Coll Anim Sci & Technol, Zhengzhou, Henan, Peoples R China

2.Hebi Inst Engn & Technol, Hebi, Henan, Peoples R China

3.Henan Yifa Anim Husb Co Ltd, Hebi, Henan, Peoples R China

4.Sanya Inst, Hainan Acad Agr Sci, Sanya, Peoples R China

关键词： body mass index; de-regressed estimated breeding values; pig; productive traits; single-step genome wide association study

期刊名称：ANIMAL GENETICS （ 影响因子：2.1； 五年影响因子：2.5 ）

ISSN： 0268-9146

年卷期： 2025 年 56 卷 1 期

页码：

收录情况： SCI

摘要： Body mass index (BMI) can serve as a reasonable indicator of overall body fat content in pigs. This study aimed to identify underlying variants and candidate genes associated with BMI in Yunong-black pigs. A single-step genome-wide association analysis (GWAS) was performed on 1405 BMI records and 924 Yunong-black pigs genotyped using a 50 K SNP Chip. De-regressed estimated breeding values were taken as the response variable in the GWAS. The estimated heritability for BMI was 0.157. Nine significant regions were associated with BMI, accounting for 12.828% of genetic variance, with the highest region explaining 1.969% of the genetic variance. Linkage disequilibrium analysis of the nine significant regions revealed that SNPs in six single-step GWAS-identified genomic regions were all located in the linkage disequilibrium blocks. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of the 29 protein-coding genes annotated to these regions revealed that FABP2, a key gene associated with BMI in human, was enriched in the fatty acid binding term and the fat digestion and absorption pathway. This study provides a better insight into the genetic architecture of the BMI trait, and offers potential molecular markers for the breeding of Yunong-black pigs.

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