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Geminiviral replication enhancer hijacks a negative regulator of cytokinin signaling to facilitate viral infection

文献类型： 外文期刊

作者： Guo, Liu-Ming 1 ; Li, Jing 1 ; Qi, Pan-Pan 1 ; Qing, Ling 2 ; Zhang, Heng-Mu 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Virol & Biotechnol, Innovat Ctr Chinese Med Crops, Lab Virol, Hangzhou 310021, Peoples R China

2.Southwest Univ, Coll Plant Protect, Chongqing Key Lab Plant Dis Biol, Chongqing 400716, Peoples R China

3.Southwest Univ, Key Lab Agr Biosafety & Green Prod Upper Yangtze R, Minist Educ, Chongqing 400716, Peoples R China

4.Southwest Univ, Natl Citrus Engn Res Ctr, Chongqing 400712, Peoples R China

关键词： viral replication enhancer; cytokinin signaling; CK; TATA-box binding protein-associated factor 12b; TAF12b; TAF12b-KMD-RR module; geminiviruses; negative regulator of CK signaling

期刊名称：PLANT COMMUNICATIONS （ 影响因子：11.6； 五年影响因子：11.8 ）

ISSN： 2590-3462

年卷期： 2025 年 6 卷 8 期

页码：

收录情况： SCI

摘要： Geminiviruses are widespread across the globe and cause devastating diseases in food and medicinal crops. Their C3 proteins have long been known to enhance viral replication; however, the underlying molecular mechanisms remain poorly understood. In this study, we show that transgenic plants overexpressing the C3 protein of tobacco curly shoot geminivirus (TbCSV) exhibit hypersensitive responses to cytokinin (CK) treatment, which largely restores the attenuated viral replication observed in the TbCSV C3 mutant (TbCSV mC3 ). We identified NbTAF12b, a negative regulator of CK signaling in Nicotiana benthamiana, as a C3-interacting protein that attenuates TbCSV replication. TbCSV C3 not only inhibits the transcription of NbTAF12b but also competes with NbRR1 and NbKMD17 for binding to the NbTAF12b protein. This competition disrupts the formation of the NbTAF12b-NbKMD-NbRR heterotrimer and promotes NbRR1 accumulation, thereby enhancing CK signaling and ultimately facilitating TbCSV replication. C3 proteins from other distantly related geminiviruses exhibit similar 3D structures and also target NbTAF12b in vivo, suggesting that this mechanism is conserved among geminiviruses. These findings shed new light on the molecular mechanism by which TbCSV C3 facilitates viral replication through the modulation of CK signaling and provide potential molecular targets for engineering virus-resistant plants.

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