您好，欢迎访问浙江省农业科学院 机构知识库！
浙江省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Protective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice

文献类型： 外文期刊

作者： Xiang, Xingwei 1 ; Jiang, Qihong 1 ; Shao, Wan 4 ; Li, Jinhong 1 ; Zhou, Yufang 5 ; Chen, Lin 6 ; Deng, Shanggui 4 ; Zheng, Bin 4 ; Chen, Yufeng 1 ;

作者机构： 1.Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou, Peoples R China

2.Key Lab Marine Biol Resources Innovat & Dev Zheji, Hangzhou, Peoples R China

3.Natl R&D Branch Ctr Pelag Aquat Prod Proc Hangzho, Hangzhou, Peoples R China

4.Zhejiang Ocean Univ, Food & Pharm Coll, Zhoushan, Peoples R China

5.Zhejiang Marine Dev Res Inst, Zhoushan, Peoples R China

6.Zhejiang Acad Agr Sci, Inst Sericultural & Tea, Hangzhou, Peoples R China

关键词： shrimp peptides; dextran sulfate sodium (DSS); ulcerative colitis; inflammatory bowel disease; intestinal flora

期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.59； 五年影响因子：6.873 ）

ISSN： 2296-861X

年卷期： 2021 年 8 卷

页码：

收录情况： SCI

摘要： Inflammatory bowel disease, an intestinal relapsing inflammatory disease, not only impairs gastrointestinal function but also increases the chances of developing colon cancer. Currently, the effects of shrimp peptide (SP) in mice model of ulcerative colitis (UC) are still unclear. In particular, it is uncertain whether SP affects the gut flora with UC mice. In this study, we investigated the anti-inflammatory effects of SP on a dextran sulfate sodium (DSS)-induced mouse model of UC. Firstly, the molecular weight of SP was mainly distributed in the range of 180-1,000 Da (61.95% proportion), and the amino acid composition showed that SP contained 17 amino acids, of which, the essential amino acids accounted for 54.50%. In vivo, oral SP significantly attenuated the severity of colitis, such as diarrhea, weight loss, and rectal bleeding. Furthermore, treatment with SP remarkably ameliorated intestinal barrier integrity, thus lowering the levels of the inflammatory cytokines and ameliorating antioxidant indices and intestinal injury indicators in the serum and colon. Lastly, the cecal contents were used to sequence and analyze the 16S rRNA genes of bacteria. Results suggested that treatment with SP could restore the balance of intestinal flora in modeled mice by regulating the abundance of pathogenic and beneficial bacteria. Furthermore, SP could significantly improve intestinal flora dysfunction in mice with UC. In summary, our findings show that SP has a prophylactic and therapeutic effect in UC in vivo, thereby highlighting its broad medicinal applications.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：浙江省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台