Preparation and Characterization of Ginger Peel Polysaccharide-Zn (II) Complexes and Evaluation of Anti-Inflammatory Activity
文献类型： 外文期刊
作者： Li, Wenwen 1 ; Qiu, Zhichang 1 ; Ma, Yue 2 ; Zhang, Bin 1 ; Li, Lingyu 1 ; Li, Qiulin 3 ; He, Qiuxia 4 ; Zheng, Zhenjia 1 ;
作者机构： 1.Shandong Agr Univ, Shandong Higher Educ Inst, Coll Food Sci & Engn, Key Lab Food Proc Technol & Qual Control, Tai An 271018, Peoples R China
2.Beijing Acad Agr & Forestry Sci, Inst Agrifood Proc & Nutr, Beijing Key Lab Agr Prod Fruits & Vegetables Prese, Key Lab Vegetable Postharvest Proc,Minist Agr & Ru, Beijing 100097, Peoples R China
3.Suzhou Univ Sci & Technol, Sch Mat Sci & Engn, Suzhou 215011, Peoples R China
4.Qilu Univ Technol, Shandong Acad Sci, Sci & Technol Serv Platform Shandong Acad Sci, Jinan 250103, Peoples R China
关键词： ginger peel polysaccharide-Zn (II) complexes; synthesis; structural characterization; anti-inflammatory activity; zebrafish
期刊名称：ANTIOXIDANTS （ 影响因子：7.675； 五年影响因子：7.886 ）
ISSN：
年卷期： 2022 年 11 卷 12 期
页码：
收录情况： SCI
摘要： The present study aimed to explore the improvement of the bioactivity of ginger peel polysaccharides (GPs) by the modification of zinc after structural characterization. The obtained GP-Zn (II) complexes consisted dominantly of glucose and galactose in a mass proportion of 95.10:2.10, with a molecular weight of 4.90 x 10(5) Da and a Zn content of 21.17 mg/g. The chelation of GPs and Zn (II) was mainly involved in the O-H of hydroxyl groups, and this interaction reduced the crystallinity and decreased the asymmetry of GPs, with a slight effect on the thermal stability. The administration of GPs and their Zn (II) complexes effectively alleviated CuSO4-induced inflammatory response in zebrafish (Tg: zlyz-EGFP) via down-regulating the mRNA expression levels of pro-inflammatory cytokines (IL-1 beta, IL-6, IL-8, IL-12 and TNF-alpha) and upregulating the expression of anti-inflammatory cytokine (IL-10). Furthermore, the modification of Zn (II) enhanced the inflammation-inhibiting effect of polysaccharides. Therefore, GP-Zn (II) complexes could be applied as a candidate anti-inflammatory agent for the treatment of chronic inflammation-related diseases.
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