Aggregation-Induced Enhanced Electrochemiluminescence from Tris(bipyridine)ruthenium(II) Derivative Nanosheets for the Ultrasensitive Detection of Human Telomerase RNA
文献类型： 外文期刊
作者： Han, Tingting 1 ; Geng, Yu-Qian 2 ; Zhang, Min 3 ; Cao, Yue 2 ; Zhu, Jun-Jie 2 ;
作者机构： 1.Jiangsu Acad Agr Sci, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base, Minist Sci & Technol,Inst Food Safety & Nutr, Nanjing 210014, Peoples R China
2.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China
3.Dongguan Univ Technol, Sch Environm & Civil Engn, Guangdong Engn & Technol Res Ctr Adv Nanomat, Dongguan 523808, Peoples R China
关键词： aggregation-induced emission; biosensing; electrochemiluminescence; human telomerase RNA; Ru-TPE nanosheets (NSs)
期刊名称：SMALL （ 影响因子：13.3； 五年影响因子：13.2 ）
ISSN： 1613-6810
年卷期： 2023 年
页码：
收录情况： SCI
摘要： The traditional tris(bipyridine)ruthenium(II) complex suffers from the notorious aggregation-caused quenching effect, which greatly compromises its electrochemiluminescence (ECL) efficiency, thus hindering further applications in biosensing and clinical diagnosis. Here, the ultrathin tetraphenylethylene-active tris(bipyridine)ruthenium(II) derivative nanosheets (abbreviated as Ru-TPE NSs) are synthesized through a protein-assisted self-assembly strategy for ultrasensitive ECL detection of human telomerase RNA (hTR) for the first time. The synthesized Ru-TPE NSs exhibit the aggregation-induced enhanced ECL behavior and excellent water-dispersion. Surprisingly, up to a 106.5-fold increase in the ECL efficiency of Ru-TPE NSs is demonstrated compared with the dispersed molecules in an organic solution. The restriction of intramolecular motions is confirmed to be responsible for the significant ECL enhancement. Therefore, this proposed ECL biosensor shows high sensitivity and excellent selectivity for hTR based on Ru-TPE NSs as efficient ECL beacons and the catalytic hairpin assembly as signal amplification, whose detection limit is as low as 8.0 fm, which is far superior to the previously reported works. Here, a promising analytical method is provided for early clinical diagnosis and a new type of efficient ECL emitters with great application prospects is represented. The ultrathin tetraphenylethylene-active tris(bipyridine)ruthenium(II) derivative nanosheets are synthesized through a protein-assisted self-assembly strategy and realize aggregation-induced enhanced electrochemiluminescence (ECL) and excellent water-dispersion. Accordingly, the ultrathin nanosheets serve as efficient ECL beacons for ultrasensitive determination of human telomerase RNA.image
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