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Assessment of recombinant Lactobacillus vector-based expressing IFITM3 protein anti-PRV infection in mice.

文献类型： 外文期刊

作者： Zheng, Fan 1 ; Zhu, Maokun 1 ; Ran, Hengdong 1 ; He, Jiayi 2 ; Bai, Binghan 1 ; Feng, Simeng 1 ; Dong, Wei 1 ; Li, Bin 3 ; Wen, Lixin 4 ; Yuan, Xiaomin 1 ;

作者机构： 1.Hunan Agr Univ HUNAU, Coll Vet Med, Changsha 410128, Hunan, Peoples R China

2.Changsha Green Leaf Bio Technol Co LTD, Changsha 410119, Hunan, Peoples R China

3.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Jiangsu, Peoples R China

4.Inst Yunnan Circular Agr Ind, Puer 665000, Yunnan, Peoples R China

关键词： Recombinant lactic acid bacteria; Interferon-induced transmembrane protein 3; Pseudorabies virus; Antiviral

期刊名称：VACCINE （ 影响因子：3.5； 五年影响因子：3.5 ）

ISSN： 0264-410X

年卷期： 2025 年 54 卷

页码：

收录情况： SCI

摘要： Pseudorabies virus (PRV) causes high mortality encephalitis in newborn piglets, abortion and stillbirth in sows, resulting in huge economic losses to the swine industry. Interferon-induced transmembrane proteins (IFITMs) play a crucial role in the innate immune response triggered by viral infection. Lactic acid bacteria (LABs) are good candidates for the development of new oral vaccines and are attractive alternatives to attenuated pathogens. "Here we tested the capacity of a LAB vector expressing the IFITM3 protein (r-LAB-I3), delivered by oral gavage, to protect mice against PRV challenge. Furthermore, the r-LAB-I3 treated groups showed markedly diminished levels of viral DNA in brain, lung, spleen and liver tissues, which resulted in protection against brain and lung damage. Moreover, the inhibitory effect of IFITM3 on PRV circumvents the upregulation of inflammatory cytokines. As r-LAB-I3 oral gavage platforms can restrict in various organs and tissues of PRV in mice, recombinant LAB may generate additional innovative and efficient live vector anti-PRV candidates.

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