Fast Screening of 10 Kinds of Illegal Aphrodisiac Drugs in Foods by Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
文献类型： 外文期刊
作者： Zeng, Xi 1 ; Wang, Yu 1 ; Chen, Ying-Li 3 ; Zhao, Tian-Tian 4 ; Xu, Zhen-Lin 2 ; Zhou, Heng-Xin 1 ;
作者机构： 1.Guangzhou Inst Food Control, Guangzhou 511400, Peoples R China
2.South China Agr Univ, Coll Food Sci, Guangdong Prov Key Lab Food Qual & Safety, Guangzhou 510642, Peoples R China
3.Guizhou Prov Detect Technol Res & Applicat Ctr, Guiyang 550016, Peoples R China
4.Guangdong Acad Agr, Minist Agr & Rural Affairs, Sericulture & Agrifood Res Inst, Guangdong Key Lab Agr Prod Proc,Key Lab Funct Food, Guangzhou 510610, Peoples R China
关键词： Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; Aphrodisiac drugs; Illegal addition; alpha-Cyano-4-hydroxycinnamic acid; Sinapic acid
期刊名称：CHINESE JOURNAL OF ANALYTICAL CHEMISTRY （ 影响因子：1.3； 五年影响因子：1.0 ）
ISSN： 0253-3820
年卷期： 2024 年 53 卷 3 期
页码：
收录情况： SCI
摘要： A matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) method was developed for simultaneous analysis of 10 kinds of aphrodisiac drugs, including sildenafil, acetildenafil, nor-acetildenafil, homosildenafil, lodenafil carbonate, sildlenafil dimer impurity, vardenafil dimer, hydroxyacetildenafil, N-desmethylsildenafil and udenafil. By using different matrices (alpha-cyano-4-hydroxycinnamic acid (HCCA) and sinapic acid (SA)), the effects of solvents, amount of matrices, laser intensity and spotting methods on the peak strength and signal intensity of MALDI-TOF MS for the aphrodisiac drugs were investigated. As a result, SA was chosen as the matrix, and then dispersed in methanol-water (50 & ratio;50, V/V), and spotted by matrix firstly and sample secondly approach with the reflect linear positive mode and laser power of 60%. Under optimal conditions, the proposed MALDI-TOF MS method could obtain stable signal, high intensity and well-repeated mass spectrometric results. The results of method validation showed a linear range from 10 to 100 ng/mL, and the regression coefficients (r) were all above 0.985. The limits of detection (LOD) were 0.1-1.0 ng/mL, and the recoveries were in the range of 72.9%-109.9% for health wine, soft capsule and instant coffee samples, while the relative standard deviations (RSDs) ranged from 0.7% to 11.3% (n = 3). The test results of 10 kinds of aphrodisiac drugs by MALDI-TOF MS were in accordance with the results of high-performance liquid chromatography-tandem mass spectrometry. This method exhibited high sensitivity, high accuracy, good anti-interference ability, low chemical solvents consumption and environmentally friendliness, and could be used to detect drugs without standards. The developed MALDI-TOF MS method could realize the non-target screening and detection of 10 kinds of illegally added aphrodisiac drugs in foods.
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