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Development and Immunoprotection of Bacterium-like Particle Vaccine against Infectious Bronchitis in Chickens

文献类型： 外文期刊

作者： Zhang, Pengju 1 ; Yang, Tiantian 2 ; Sun, Yixue 3 ; Qiao, Haiying 1 ; Hu, Nianzhi 1 ; Li, Xintao 1 ; Wang, Weixia 1 ; Zhang, Lichun 1 ; Cong, Yanlong 2 ;

作者机构： 1.Jilin Acad Agr Sci, Inst Anim Biotechnol, Changchun 130033, Peoples R China

2.Jilin Univ, Coll Vet Med, Lab Infect Dis, Key Lab Zoonosis Res,Minist Educ, Changchun 130062, Peoples R China

3.Changchun Univ, Dept Pol & Regulat, Changchun 130022, Peoples R China

关键词： infectious bronchitis virus; S1 subunit; bacterium-like particles; immunoprotective

期刊名称：VACCINES （ 影响因子：7.8； 五年影响因子：7.4 ）

ISSN：

年卷期： 2023 年 11 卷 8 期

页码：

收录情况： SCI

摘要： Infectious bronchitis (IB) is a major threat to the global poultry industry. Despite the availability of commercial vaccines, the IB epidemic has not been effectively controlled. The exploration of novel IBV vaccines may provide a new way to prevent and control IB. In this study, BLP-S1, a bacterium-like particle displaying the S1 subunit of infectious bronchitis virus (IBV), was constructed using the GEM-PA surface display system. The immunoprotective efficacy results showed that BLP-S1 can effectively induce specific IgG and sIgA immune responses, providing a protection rate of 90% against IBV infection in 14-day-old commercial chickens. These results suggest that BLP-S1 has potential for the development of novel vaccines with good immunogenicity and immunoprotection.

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