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Examination of camptothecin and 10-hydroxycamptothecin in Camptotheca acuminata plant and cell culture, and the affected yields under several cell culture treatments

文献类型： 外文期刊

作者： Pi, Yan 1 ; Jiang, Keji 2 ; Hou, Rong 1 ; Gong, Yifu 3 ; Lin, Juan 1 ; Sun, Xiaofen 1 ; Tang, Kexuan 1 ;

作者机构： 1.Fudan Univ, Fudan SJTU Nottingham Plant Biotechnol R&D Ctr, Morgan Tan Int Ctr Life Sci, State Key Lab Genet Engn,Sch Life Sci, Shanghai 200433, Peoples R China

2.Chinese Acad Fishery Sci, E China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China

3.Ningbo Univ, Fac Life Sci & Biotechnol, Ningbo 315211, Zhejiang, Peoples R China

4.Shanghai Jiao Tong Univ, Inst Syst Biol,

关键词： HPLC;salicylic acid;UV-B

期刊名称：BIOCELL （ 影响因子：1.254； 五年影响因子：0.924 ）

ISSN： 0327-9545

年卷期： 2010 年 34 卷 3 期

页码：

收录情况： SCI

摘要： Camptothecin and its derivatives are monoterpenoid indole alkaloids exhibiting significant anti-tumor actions. With the aim of improving the production or these pharmaceuticals, the contents of camptothecin and 10-hydroxycamptothecin in different tissues including roots, stems, leaves, young flower buds, opening flowers, fading flowers and seeds from Camptotheca acuminata, were investigated. The young flower buds had the highest alkaloid concentrations (camptothecin, 2.46 mg/g of dry weight; 10-hydroxycamptothecin, 1.41 mg/g of dry weight). Callus showed lower concentrations but it should also be considered as a potential source of these pharmaceuticals. In the present study, the growth rate of Camptotheca acuminata cells in culture did not correlate with contents of camptothecin and 10-hydroxycamptothecin. Alkaloid accumulation by cells under various treatments (heavy metal ions, UV-B), methyl-jasmonate, abscisic acid, salicylic acid and hydrogen peroxide was examined, and the most notable effects appeared in the cells induced by UV-B light (which showed an 11-fold increase in camptothecin concentration) and by salicylic acid (which showed a 25-fold increase in 10-hydroxycamptothecin concentration). These results are significant in the context of the production of both pharmaceuticals.

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