Allelic variation, balancing selection and positive selected sites detected from MHC class I alpha gene of olive flounder
文献类型： 外文期刊
作者： Xu, Tian-jun 2 ; Sun, Yue-na 2 ; Chen, Song-lin 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Minist Agr, Key Lab Sustainable Utilizat Marine Fisheries Res, Qingdao 266071, Peoples R China
2.Zhejiang Ocean Univ, Coll Marine Sci, Key Lab Marine Living Resources & Mol Engn, Zhoushan 316000, Peoples R China
关键词： Olive flounder (Paralichthys olivaceus);Major histocompatibility complex;Allelic variation;Balancing selection
期刊名称：GENETICA （ 影响因子：1.082； 五年影响因子：1.489 ）
ISSN： 0016-6707
年卷期： 2010 年 138 卷 11-12 期
页码：
收录情况： SCI
摘要： Major histocompatibility complex (MHC) genes play an important role in the immune response of vertebrates. Allelic polymorphism and pattern of evolution in MHC genes has been investigated in many mammals, however, much less is known in teleost. In the present study, we have investigated complete MHC I alpha gene consists of 7 exons and 6 introns in Olive flounder (Paralichthys olivaceus). Genetic variation in the MHC class I alpha gene was also tested in flounder. In 32 individuals, a total of 62 alleles were detected from exon 2 of MHC class I alpha gene. The rate of non-synonymous substitutions (d (N) ) occurred at a significantly higher frequency than that of synonymous substitutions (d (S) ) in PBR and non-PBR, suggesting that balancing selection for maintaining polymorphisms at the MHC I alpha locus. Many positive selection sites were found to act very intensively on antigen binding sites. Our founding suggests a snapshot in an evolutionary process of MHC I alpha gene evolution of the P. olivaceus.
- 相关文献
作者其他论文 更多>>
-
Transcriptome analysis of Giant grouper (Epinephelus lanceolatus) kidney and spleen in response to spotted knifejaw iridovirus (SKIV) infection
作者：Zheng, Gui-liang;Hu, Guobin;Zheng, Gui-liang;Zhou, Qian;Li, Kun-ming;Xu, Wen-teng;Wang, Lei;Chen, Song-lin;Zhou, Qian;Li, Kun-ming;Xu, Wen-teng;Wang, Lei;Chen, Song-lin;Zhou, Qian;Li, Kun-ming;Xu, Wen-teng;Wang, Lei;Chen, Song-lin
关键词：giant grouper; innate immunity; signalling pathway; spotted knifejaw iridovirus; transcriptome
-
Development of a 50K SNP Array for Japanese Flounder and Its Application in Genomic Selection for Disease Resistance
作者：Zhou, Qian;Chen, Ya-dong;Lu, Sheng;Liu, Yang;Xu, Wen-teng;Li, Yang-zhen;Wang, Lei;Wang, Na;Yang, Ying-ming;Chen, Song-lin;Zhou, Qian;Xu, Wen-teng;Wang, Na;Chen, Song-lin
关键词：Paralichthys olivaceus; Single nucleotide polymorphism; SNP array; Disease resistance; Genomic selection
-
Genome-wide identification, characterization, and expression analysis of the TRAF gene family in Chinese tongue sole (Cynoglossus semilaevis)
作者：Li, Kun-ming;Li, Ming;Wang, Na;Chen, Ya-dong;Xu, Xi-wen;Xu, Wen-teng;Wang, Lei;Chen, Song-lin;Li, Kun-ming;Li, Ming;Wang, Na;Chen, Ya-dong;Xu, Xi-wen;Xu, Wen-teng;Wang, Lei;Chen, Song-lin;Li, Kun-ming;Li, Ming
关键词：TRAF; Cynoglossus semilaevis; Bacterial infection; Innate immune; Overexpression
-
Draft genomes of female and male turbot Scophthalmus maximus
作者：Xu, Xi-wen;Shao, Chang-wei;Xu, Hao;Zhou, Qian;Wang, Na;Li, Wen-long;Li, Ming;Chen, Song-lin;Xu, Xi-wen;Shao, Chang-wei;Zhou, Qian;Wang, Na;Chen, Song-lin;Xu, Hao;Li, Ming;You, Feng
关键词：
-
Sex Identification and Control in Half-Smooth Tongue Sole
作者：Chen, Song-Lin;Xu, Wen-Teng
关键词：
-
Genomic and Epigenetic Aspects of Sex Determination in Half-Smooth Tongue Sole
作者：Chen, Song-Lin;Shao, Chang-Wei;Zhou, Qian
关键词：
-
Sex-Specific Markers, Gynogenesis, and Sex Control in Spotted Halibut
作者：Ma, Hong-Yu;Chen, Song-Lin;Ji, Xiang-Shan
关键词：
