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MHC class II alpha gene polymorphism and its association with resistance/susceptibility to Vibrio anguillarum in Japanese flounder (Paralichthys olivaceus)

文献类型： 外文期刊

作者： Xu, Tian-jun 1 ; Chen, Song-lin 1 ; Zhang, Yu-xi 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Minist Agr, Yellow Sea Fisheries Res Inst, Key Lab Sustainable Utilizat Marine Fisheries Res, Qingdao 266071, Peoples R China

2.Zhejiang Ocean Univ, Coll Marine Sci, Key Lab Marine Living Resources & Mol Engn, Zhoushan 316000, Peoples R China

关键词： Paralichthys olivaceus;Major histocompatiblity complex II alpha;Bacterial infections;Vibrio anguillarum;Disease resistance

期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：3.636； 五年影响因子：3.654 ）

ISSN： 0145-305X

年卷期： 2010 年 34 卷 10 期

页码：

收录情况： SCI

摘要： Association between polymorphism of the major histocompatibility complex (MHC) genes and disease resistance has been documented for few teleosts. In this study, we first investigate the genetic variation at the MHC II alpha gene in Japanese flounder (Paralichthys olivaceus) for survival after challenge with bacterial infection. To explore the specific allele associated with disease resistance, about 6000 individuals from 60 families challenged with Vibrio anguillarum, which causes significantly different mortality in flounder families. 15-20 individuals from each of six high-resistance (HR) and six low-resistance (LR) families were screened for their MHC class II alpha genotypes using sequence analysis. High polymorphism of MHC II alpha gene and at least two loci were discovered in Japanese flounder and the rate of d(N) occurred at a significantly higher frequency than that of d(s) in PBR and non-PBR, the balancing selection hypothesis could explain the high polymorphism of MHC II alpha gene in flounder. From the 212 individuals, a total of 55 MHC class II alpha alleles were identified, and 9 alleles were used to study association between alleles and resistance to disease. Three alleles, Paol-DAA*1301, Paol-DAA*1401 and Paol-DAA*2201 were significantly associated with resistance against V. anguillarum, and Paol-DAA*1001 and Paol-DAA*1501 alleles were significantly associated with increased susceptibility to V. anguillarum. This study confirmed the association between alleles of MHC class Ha gene and disease resistance or susceptibility to bacterial infection in flounder, and the disease resistance-related MHC markers could be used for molecular marker-assisted selective breeding in the flounder. (C) 2010 Elsevier Ltd. All rights reserved.

  • 相关文献

[1]MHC polymorphism and disease resistance to Vibrio anguillarum in 12 selective Japanese flounder (Paralichthys olivaceus) families. Xu, Tian-jun,Chen, Song-lin,Ji, Xiang-shan,Tian, Yong-sheng,Xu, Tian-jun. 2008

[2]A Genome Scan for Quantitative Trait Loci Associated with Vibrio anguillarum Infection Resistance in Japanese Flounder (Paralichthys olivaceus) by Bulked Segregant Analysis. Wang, Lei,Wang, Lei,Fan, Caixia,Liu, Yang,Zhang, Yingping,Deng, Han,Xu, Ying,Tian, Yongsheng,Liao, Xiaolin,Xie, Mingshu,Li, Wenlong,Chen, Songlin,Wang, Lei,Liu, Shoutang,Sun, Deqiang.

[3]Cloning of Disease Resistance-relevant Nramp and MHC IIB Genes and their Application Potential in Molecular Breeding for Disease Resistance in Japanese Flounder (Paralichthys olivaceus). S.L. Chen,Y.X. Zhang,Z.J. Wang,Z.X. Sha,M.Y. Xu,Chinese Academy of Fishery Sciences; Chinese Academy of Sciences;. 2005

[4]Genetic diversity in three Japanese flounder (Paralichthys olivaceus) populations revealed by ISSR markers. Liu, YG,Chen, SL,Li, J,Li, BF. 2006

[5]Molecular identification and expression analysis of natural resistance associated macrophage protein (Nramp) cDNA from Japanese flounder (Paralichthys olivaceus). Chen, SL,Wang, ZJ,Xu, MY,Gui, JF. 2006

[6]Genetic differentiation among common and selected hatchery populations of founder: Evidence from RAPD markers. Liu, Yun-Guo,Chen, Song-Lin,Li, Ba-Fang. 2007

[7]Phenotypic and genetic parameter estimation of morphological traits related to axial body growth in Japanese flounder. Liu, Yong-Xin,Jiang, Li,Liu, Hai-Jin,Yang, Run-Qing. 2014

[8]Assessing the genetic structure of three Japanese flounder (Paralichthys olivaceus) stocks by microsatellite markers. Liu, YG,Chen, SL,Li, BF. 2005

[9]Larval development and salinity tolerance of Japanese flounder (Paralichthys olivaceus) from hatching to juvenile settlement. Wang, Youji,Guo, Qindan,Zhao, Hu,Lu, Weiqun,Liu, Haijin.

[10]Generation and evaluation of virulence attenuated mutants of Edwardsiella tarda as vaccine candidates to combat edwardsiellosis in flounder (Paralichthys olivaceus). Li, Jie,Mo, Zhaolan,Li, Guiyang,Huang, Jie,Li, Jie,Mo, Zhaolan,Li, Guiyang,Huang, Jie,Xiao, Peng.

[11]Estimation of genetic parameters for growth related traits at different stages of development in Paralichthys olivaceus (Temminck & Schlegel, 1846). Liu, F.,Liu, F.,Chen, S. L.,Wang, L.,Zhang, Y. P.,Tian, Y. S.,Chen, H. L.,Liu, F.,Chen, S. L.,Wang, L.,Zhang, Y. P.,Tian, Y. S.,Chen, H. L.,Wang, L.,Chen, H. L..

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[13]Genetic verification of doubled haploid Japanese flounder, Paralichthys olivaceus by genotyping telomeric microsatellite loci. Liu, Yongxin,Liu, Haijin,Wang, Guixing,Wang, Yufen,Si, Fei,Sun, Zhaohui,Zhang, Xiaoyan,Liu, Yi,Hou, Jilun. 2012

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[15]Stable cell-surface expression of Japanese flounder growth hormone in yeast Saccharomyces cerevisiae and growth-promoting effect on juvenile fish by oral administration. Zang, Xiao-Nan,Zhang, Xue-Cheng,Liu, Bin,Liu, Xin-Fu,Lei, Ji-Lin. 2012

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[18]Optimization of the purification methods for recovery of recombinant growth hormone from Paralichthys olivaceus. Liu Bin,Zang Xiaonan,Zhang Xuecheng,Mu Xiaosheng. 2013

[19]Construction and comparative study of monovalent and multivalent DNA vaccines against Streptococcus iniae. Sun, Yun,Hu, Yong-Hua,Sun, Li,Sun, Yun,Liu, Chun-Sheng.

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