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Effect of a human pharmaceutical carbamazepine on antioxidant responses in brain of a model teleost in vitro: an efficient approach to biomonitoring

文献类型： 外文期刊

作者： Li, Zhi-Hua 1 ; Li, Ping 1 ; Randak, Tomas 1 ;

作者机构： 1.Univ S Bohemia Ceske Budejovice, Fac Fisheries & Protect Waters, Res Inst Fish Culture & Hydrobiol, Vodnany 38925, Czech Republic

2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Jinzhou 434000, Peoples R China

关键词： residual pharmaceutical;fish brain;in vitro oxidative damage;biomonitoring

期刊名称：JOURNAL OF APPLIED TOXICOLOGY （ 影响因子：3.446； 五年影响因子：3.727 ）

ISSN： 0260-437X

年卷期： 2010 年 30 卷 7 期

页码：

收录情况： SCI

摘要： Residual pharmaceuticals are generally recognized as relevant sources of aquatic environmental pollutants In this study, the effects of carbamazepine (CBZ) on the antioxidant defense system in the brain of rainbow trout in vitro were studied The brain homogenates were incubated with various concentrations of CBZ (1 0 mu g l(-1), 0 2 mg l(-1) or 2 0 mg l(-1)) for 0, 60, 120 min After incubation, oxidative stress indices (lipid peroxidation and carbonyl protein), antioxidant enzymes (superoxide dismutase, glutathione reductase and glutathione peroxidase) and nonenzymatic antioxidant (reduced glutathione) in each samples were measured Based on the results, the brain homogenates performed adaptive responses to CBZ-induced stress at environmental concentration (1 0 mu g l(-1),) With increased CBZ concentrations (0 2 or 2 0 mg l(-1)), oxidative stress was apparent as reflected by the significant higher levels of oxidative indices, together with the significant inhibition of all antioxidant enzymes activities and reduced glutathione content Compared with previous studies in vivo, the brain homogenates showed more sensitive antioxidant responses to CBZ stress In conclusion, the brain homogenates of rainbow trout could be used as an efficient model system in aquatic risk assessment, but more detailed laboratory studies are needed before these findings could be established as special biomarkers for monitoring residual pharmaceuticals in aquatic environment Copyright (C) 2010 John Wiley & Sons, Ltd

  • 相关文献

[1]Effects of exposure to sublethal propiconazole on the antioxidant defense system and Na+-K+-ATPase activity in brain of rainbow trout, Oncorhynchus mykiss. Li, Zhi-Hua,Zlabek, Vladimir,Grabic, Roman,Li, Ping,Machova, Jana,Velisek, Josef,Randak, Tomas,Li, Zhi-Hua,Li, Ping,Grabic, Roman. 2010

[2]Enzymatic alterations and RNA/DNA ratio in intestine of rainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine. Li, Zhi-Hua,Zlabek, Vladimir,Grabic, Roman,Velisek, Josef,Machova, Jana,Randak, Tomas,Li, Zhi-Hua,Grabic, Roman. 2010

[3]Chronic toxicity of verapamil on juvenile rainbow trout (Oncorhynchus mykiss): Effects on morphological indices, hematological parameters and antioxidant responses. Li, Zhi-Hua,Velisek, Josef,Zlabek, Vladimir,Grabic, Roman,Machova, Jana,Kolarova, Jitka,Li, Ping,Randak, Tomas,Li, Zhi-Hua,Li, Ping.

[4]Effect of human pharmaceutical Carbamazepine on the quality parameters and oxidative stress in common carp (Cyprinus carpio L.) spermatozoa. Li, Zhi-Hua,Li, Ping,Rodina, Marek,Randak, Tomas,Li, Zhi-Hua,Li, Ping.

[5]Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin. Li, Zhi-Hua,Li, Ping,Shi, Ze-Chao,Li, Zhi-Hua,Li, Ping.

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