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Toxic threshold of dietary microcystin (-LR) for quart medaka

文献类型： 外文期刊

作者： Deng, Dong-Fang 1 ; Zheng, Keke 3 ; Teh, Foo-Ching 1 ; Lehman, Peggy W. 4 ; Teh, Swee J. 1 ;

作者机构： 1.Univ Calif Davis, Sch Vet Med, Ctr Hlth, Davis, CA 95616 USA

2.Univ Calif Davis, Sch Vet Med, Environm & Aquat Toxicol Program, Davis, CA 95616 USA

3.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China

4.Dept Water Resources, Div Environm Serv, Sacramento, CA 95691 USA

关键词： Apoptosis;Microcystin;Medaka;Protein phosphatase;Reproduction;Stress protein

期刊名称：TOXICON （ 影响因子：3.033； 五年影响因子：2.689 ）

ISSN： 0041-0101

年卷期： 2010 年 55 卷 4 期

页码：

收录情况： SCI

摘要： This study was designed to estimate the toxic threshold of male and female fish to microcystins based on different biomarkers. Japanese medaka (Oryzias latipes) were fed dietary Microcystin-LR (0, 0.46, 0.85, 2.01 and 3.93 mu g MC-LR/g dry diet for 8 weeks at 25 degrees C. The results revealed that dietary MC-LR inhibited growth at the end of 8 weeks. The survival of embryos and the RNA/DNA ratio of whole fish decreased significantly (P < 0.05) in fish fed 3.93 mu g MC-LR/g dry diet. Heat shock protein (Hsp60) expression was induced in the liver of female and male fish fed diets containing >= 0.85 and 0.46 mu g MC-LR/g diet, respectively. The activity of liver caspase 3/7 was significantly higher in female fish fed 3.93 mu g MC-LR/g diet and in males fed 2.01 MC-LR mu g/g dry diet than fish fed the control diet. The threshold for inhibition of liver protein phosphatase expression was lower in female (2.01 mu g/g diet) than that in male fish (3.93 mu g/g diet). Histopathological examination showed significant single-cell necrosis in female and male medaka fed diets containing 0.85 and 3.93 mu g MC-LR/g diet, respectively. Based on different biomarkers, this study demonstrated that dietary MC-LR is toxic to Medaka and the effects are gender dependent. Published by Elsevier Ltd.

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