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Effects of pectin with distinct structural characteristics on gut microbiota composition and metabolite profiles in naive mice

文献类型： 外文期刊

作者： Zou, Ping 1 ; Zhao, Yuanyuan 1 ; Wang, Dan 1 ; Zhao, Wenting 1 ; Ge, Zhiwen 1 ; Wang, Pan 1 ; Zhao, Xiaoyan 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Agrifood Proc & Nutr, Beijing Key Lab Agr Prod Fruits & Vegetables Prese, Key Lab Vegetable Postharvest Proc,Minist Agr & Ru, Beijing 100097, Peoples R China

2.Shenyang Agr Univ, Coll Food Sci, Shenyang 110866, Liaoning, Peoples R China

关键词： Pectin esterification; Gut microbiota; Tryptophan metabolite

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 319 卷

页码：

收录情况： SCI

摘要： Pectin, a dietary polysaccharide, has been proven to have numerous health benefits. However, the relationship between pectin's structure characteristics-specifically degree of esterification (DE) and molecular weight (MW)-and their influence on gut microbiota ecology remains incompletely understood. This study investigated the effects of four structurally distinct citrus pectins varying in DE (T26: 26 %, T36: 36 %, T52: 52 %, and T71: 71 %) and corresponding MW (T26: 394 kDa, T36: 752 kDa, T52: 929 kDa, and T71:1099 kDa) on intestinal microbiota composition in healthy murine models. While physiological parameters remained unchanged across treatment groups. 16s rRNA Sequencing analysis revealed that low-esterification pectin enhanced the abundance of Dubosiella, whereas high-esterification pectin variants increased Faecalibaculum and Bifidobacterium abundance. Notably, the abundance of Allobaculum exhibited a positive correlation with both DE and MW of pectin, whereas Akkermansia and Mucispirillum demonstrated negative correlations with these structural parameters. Metabolomic profiling of fecal samples revealed distinct patterns of microbial-derived metabolites across treatment groups. Low-esterification pectins (T26, T36) significantly elevated concentrations of 4-(2-aminophenyl)-2,4-dioxobutanoic acid and inositol cyclic phosphate, while high-esterification variants (T52, T71) enhanced 3-(Indol-3-yl) propionic acid and indole-3-acetic acid production. These data provide evidence for differential effects of different types of pectin on the gut microbiota and metabolic health.

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