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Crosstalk between regulatory non-coding RNAs and oxidative stress in Parkinson's disease

文献类型： 外文期刊

作者： Zhang, Hantao 1 ; Liu, Xiaoyan 1 ; Liu, Yi 1 ; Liu, Junlin 1 ; Gong, Xun 3 ; Li, Gang 4 ; Tang, Min 1 ;

作者机构： 1.Jiangsu Univ, Sch Life Sci, Zhenjiang, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Anim Husb, Nanjing, Peoples R China

3.Jiangsu Univ, Affiliated Hosp, Dept Rheumatol & Immunol, Zhenjiang, Peoples R China

4.Shandong First Med Univ, Affiliated Hosp 2, Dept Vasc Surg, Tai An, Peoples R China

关键词： Parkinson's disease; microRNAs; long non-coding RNAs; circular RNAs; oxidative stress

期刊名称：FRONTIERS IN AGING NEUROSCIENCE （ 影响因子：5.702； 五年影响因子：6.223 ）

ISSN： 1663-4365

年卷期： 2022 年 14 卷

页码：

收录情况： SCI

摘要： Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease, which imposes an ever-increasing burden on society. Many studies have indicated that oxidative stress may play an important role in Parkinson's disease through multiple processes related to dysfunction or loss of neurons. Besides, several subtypes of non-coding RNAs are found to be involved in this neurodegenerative disorder. However, the interplay between oxidative stress and regulatory non-coding RNAs in Parkinson's disease remains to be clarified. In this article, we comprehensively survey and overview the role of regulatory ncRNAs in combination with oxidative stress in Parkinson's disease. The interaction between them is also summarized. We aim to provide readers with a relatively novel insight into the pathogenesis of Parkinson's disease, which would contribute to the development of pre-clinical diagnosis and treatment.

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