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Mechanisms of Amomum villosum essential oil in enhancing tilapia ( Oreochromis niloticus) intestinal health

文献类型： 外文期刊

作者： Zeng, Xiangbing 1 ; Zheng, Xiaoting 1 ; Li, Chenghui 1 ; Ming, Junchao 1 ; Dong, Hongbiao 1 ; Zhang, Jiasong 1 ;

作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploita, Minist Agr & Rural Affairs, Guangzhou 510300, Peoples R China

2.Ocean Univ China, Key Lab Mariculture, Minist Educ, Qingdao 266003, Peoples R China

3.Key Lab Efficient Utilizat & Proc Marine Fishery R, Lingshui 572426, Peoples R China

4.Zhejiang Ocean Univ, Natl Aquaculture Engn Technol Res Ctr, Zhoushan 316000, Peoples R China

关键词： Tilapia; Essential oil; Intestinal inmmune; Transcriptome; Metabolomics

期刊名称：AQUACULTURE REPORTS （ 影响因子：3.7； 五年影响因子：4.0 ）

ISSN： 2352-5134

年卷期： 2024 年 39 卷

页码：

收录情况： SCI

摘要： Amomum villosum is a member of the ginger family to treat gastrointestinal diseases in humans. Supplementing the diet of tilapia ( Oreochromis niloticus) with essential oil (EOA) can enhance digestive and intestinal antioxidant capacity. We conducted a comparative experiment using tilapia to further understand the potential molecular response mechanism to dietary EOA. Fish were divided into four groups with different feeding doses of EOA: L (2 g/Kg) group, M (4 g/Kg) group, and H (8 g/Kg) group, along with a control group without EOA supplementation. The level of inflammatory factors (TNF-alpha, IL-1) declined significantly in the EOA group. Comparative transcriptome of the intestines revealed differentially expressed genes (DEGs) in each group, which further revealed that enriched terms were closely related to important pathways such as PI3K-Akt signaling, cell adhesion molecules, regulation of actin cytoskeleton, and autoimmune thyroid disease. These pathways play significant roles in regulating various cellular processes and immune responses of intestines. Intestine metabolomic analysis indicated that dietary EOA caused changes in metabolic processes, particularly in nucleotide metabolism, indicating the potential impact of EOA on these processes. To identify key factors regulating the molecular response to EOA supplementation, a weighted gene co-expression network analysis combined with transcriptome and differential metabolites to identify key genes and metabolites. Glycitein and genistein are substances related to the metabolism of soybean meal were identified. Hmgb2, Parp11, Bcoll is considered to be the key genes, and has the immune regulation function. This study provides new insights into the molecular basis underlying the protective effects of dietary EOA in tilapia. The results can benefit the aquaculture industry by developing dietary strategies to improve the health and welfare of tilapia in intensive farming.

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