Translocon Subunits of the COP9 Signalosome Complex Are a Central Hub for Regulating Multiple Photoresponsive Processes and Autophagic Flux in Magnaporthe oryzae
文献类型： 外文期刊
作者： Lin, Lili 1 ; Guo, Hengyuan 2 ; Batool, Wajjiha 1 ; Lin, Lianyu 1 ; Cao, Jiaying 1 ; An, Qiuli 1 ; Aliyu, Sami Rukaiya 1 ; Bao, Jiandong 1 ; Wang, Zonghua 1 ; Norvienyeku, Justice 2 ;
作者机构： 1.Fujian Agr & Forestry Univ, Coll Plant Protect, State Key Lab Ecol Pest Control Fujian & Taiwan Cr, Fuzhou 350002, Fujian, Peoples R China
2.Hainan Univ, Sch Trop Agr & Forestry, Key Lab Green Prevent & Control Trop Plant Dis & P, Minist Educ, Haikou 570228, Hainan, Peoples R China
3.Minjiang Univ, Inst Oceanog, Fuzhou 350108, Fujian, Peoples R China
4.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou 310021, Zhejiang, Peoples R China
关键词： autophagic flux; microbial pathogenesis; cAMPaccumulation; COP9 signalosome complex; signal transduction
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）
ISSN： 0021-8561
年卷期： 2024 年 72 卷 40 期
页码：
收录情况： SCI
摘要： Photodependent processes, including circadian rhythm, autophagy, ubiquitination, neddylation/deneddylation, and metabolite biosynthesis, profoundly influence microbial pathogenesis. Although a photomorphogenesis signalosome (COP9/CSN) has been identified, the mechanism by which this large complex contributes to the pathophysiological processes in filamentous fungi remains unclear. Here, we identified eight CSN complex subunits in the rice blast fungus Magnaporthe oryzae and functionally characterized the translocon subunits containing a nuclear export or localization signal (NES/NLS). Targeted gene replacement of these CSN subunits, including MoCSN3, MoCSN5, MoCSN6, MoCSN7, and MoCSN12, attenuated vegetative growth and conidiation and rendered the deletion strains nonpathogenic. MoCSN7 deletion significantly suppressed arachidonic acid catabolism, and compromised cell wall integrity in M. oryzae. Surprisingly, we also discovered that MoCSN subunits, particularly MoCsn7, are required for the cAMP-dependent regulation of autophagic flux. Therefore, MoCSN significantly contributes to morphological, physiological, and pathogenic differentiation in M. oryzae by fostering cross-talk between multiple pathways.
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