文献类型： 外文期刊
作者： Yan, Jongyi 1 ; Li, Lin 1 ; Bao, Jiandong 1 ; Wang, Jiaoyu 1 ; Liu, Xiaohong 2 ; Lin, Fucheng 1 ; Zhu, Xueming 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, State Key Lab Managing Biot & Chem Threats Qual &, Zhejiang Prov Key Lab Agr Microbiom,Key Lab Agr Mi, Hangzhou, Zhejiang, Peoples R China
2.Zhejiang Univ, Inst Biotechnol, State Key Lab Managing Biot & Chem Threats Qual &, Zhejiang Prov Key Lab Agr Microbiom,Key Lab Agr Mi, Hangzhou, Zhejiang, Peoples R China
3.Xianghu Lab, Hangzhou, Xianghu, Peoples R China
关键词： Magnaporthe oryzae; protein structure; drug targets; structure-based drug design
期刊名称：VIRULENCE （ 影响因子：5.4； 五年影响因子：5.7 ）
ISSN： 2150-5594
年卷期： 2024 年 15 卷 1 期
页码：
收录情况： SCI
摘要： The filamentous fungus Magnaporthe oryzae is widely recognized as a notorious plant pathogen responsible for causing rice blasts. With rapid advancements in molecular biology technologies, numerous regulatory mechanisms have been thoroughly investigated. However, most recent studies have predominantly focused on infection-related pathways or host defence mechanisms, which may be insufficient for developing novel structure-based prevention strategies. A substantial body of literature has utilized cryo-electron microscopy and X-ray diffraction to explore the relationships between functional components, shedding light on the identification of potential drug targets. Owing to the complexity of protein extraction and stochastic nature of crystallization, obtaining high-quality structures remains a significant challenge for the scientific community. Emerging computational tools such as AlphaFold for structural prediction, docking for interaction analysis, and molecular dynamics simulations to replicate in vivo conditions provide novel avenues for overcoming these challenges. In this review, we aim to consolidate the structural biological advancements in M. oryzae, drawing upon mature experimental experiences from other species such as Saccharomyces cerevisiae and mammals. We aim to explore the potential of protein construction to address the invasion and proliferation of M. oryzae, with the goal of identifying new drug targets and designing small-molecule compounds to manage this disease.
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