The endosomal-vacuolar transport system acts as a docking platform for the Pmk1 MAP kinase signaling pathway in Magnaporthe oryzae
文献类型： 外文期刊
作者： Wang, Qing 1 ; Wang, Jing 2 ; Huang, Zhicheng 1 ; Li, Yan 1 ; Li, Hui 1 ; Huang, Pengyun 3 ; Cai, Yingying 2 ; Wang, Jiaoyu 2 ; Liu, Xiaohong 4 ; Lin, Fu-Cheng 1 ; Lu, Jianping 1 ;
作者机构： 1.Zhejiang Univ, Coll Life Sci, Xianghu Lab, Hangzhou 310058, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Agr Microbiome MARA & Zhejiang Prov,Key La, Hangzhou 310021, Peoples R China
3.Linyi Univ, Sch Med, Linyi 276000, Shandong, Peoples R China
4.Zhejiang Univ, Inst Biotechnol, Hangzhou 310058, Peoples R China
关键词： appressorium; endosome; MAPK; Pmk1; rice blast fungus; signal; ubiquitination; vacuole
期刊名称：NEW PHYTOLOGIST （ 影响因子：8.1； 五年影响因子：10.3 ）
ISSN： 0028-646X
年卷期： 2025 年 245 卷 2 期
页码：
收录情况： SCI
摘要： In Magnaporthe oryzae, the Pmk1 MAP kinase signaling pathway regulates appressorium formation, plant penetration, effector secretion, and invasive growth. While the Mst11-Mst7-Pmk1 cascade was characterized two decades ago, knowledge of its signaling in the intracellular network remains limited. In this study, we demonstrate that the endosomal surface scaffolds Pmk1 MAPK signaling and Msb2 activates Ras2 on endosomes in M. oryzae. Protein colocalization demonstrated that Msb2, Ras2, Cap1, Mst50, Mst11, Mst7, and Pmk1 attach to late endosomal membranes. Damage to the endosome-vacuole transport system influences Pmk1 phosphorylation. When Msb2 senses a plant signal, it internalizes and activates Ras2 on endosome membrane surfaces, transmitting the signal to Pmk1 via Mst11 and Mst7. Signal-sensing and delivery proteins are ubiquitinated and sorted for degradation in late endosomes and vacuoles, terminating signaling. Plant penetration and lowered intracellular turgor are required for the transition from late endosomes to vacuoles in appressoria. Our findings uncover an effective mechanism that scaffolds and controls Pmk1 MAPK signaling through endosomal-vacuolar transport, offering new knowledge for the cytological and molecular mechanisms by which the Pmk1 MAPK pathway modulates development and pathogenicity in M. oryzae.
- 相关文献
作者其他论文 更多>>
-
Hue-change coupled with CRISPR-Cas12a lateral flow assay for the semiquantitative detection of Salmo salar adulteration
作者：Yuan, Jingrui;Wang, Liu;He, Fang;He, Kaiyu;Wang, Hongmei;Xu, Xiahong;Yuan, Jingrui;Huang, Liang;Wang, Jing;Xu, Xiahong
关键词：Hue change; CRISPR-Cas12a; Lateral flow assay; Quantitative analysis; Salmo salar adulteration
-
A multilayered regulatory network mediated by protein phosphatase 4 controls carbon catabolite repression and de-repression in Magnaporthe oryzae
作者：Huang, Zhicheng;Wang, Qing;Li, Yan;Li, Hui;Lin, Fu-Cheng;Lu, Jianping;Huang, Pengyun;Liao, Jian;Liu, Xiaohong;Lin, Fu-Cheng;Wang, Jing;Cai, Yingying;Wang, Jiaoyu;Lin, Fu-Cheng
关键词：
-
Carbon Dots@Upconversion Nanoparticles: Conjugate Manipulation and Luminophor Confinement Enabling Aqueous-Phase Orthogonal Multicolor Phosphorescence-Upconversion Luminescence
作者：Shao, Kang;Jin, Yuqian;Pan, Zaifa;Shi, Yike;Chen, Jiahong;Wang, Jing;She, Yuanbin;Ye, Shiyi
关键词：aqueous-phase phosphorescence; carbon dots; multicolor luminescence; orthogonal luminescence; upconversion nanoparticles
-
Integrating RNA Interference and Nanotechnology: A Transformative Approach in Plant Protection
作者：Islam, Mohammad Shafiqul;Noman, Muhammad;Zhang, Zhen;Wang, Jing;Lu, Ziqi;Cai, Yingying;Wang, Yanli;Wang, Jiaoyu;Islam, Mohammad Shafiqul;Li, Bin;Islam, Mohammad Shafiqul;Li, Bin;Ahmed, Md Robel;Ahmed, Temoor;Ahmed, Temoor;Sarwar, Abul Khayer Mohammad Golam
关键词：fungal disease; nanotechnology; plant protection; plant-pathogen interactions; RNAi
-
Effects of fructooligosaccharides and Lactobacillus reuteri on the composition and metabolism of gut microbiota in students
作者：Xu, Xu;Qu, Daofeng;Xu, Xu;Fu, Hao;Quan, Huihui;Li, Yan;Chen, Qiaoyun;Pi, Xionge
关键词：
-
Comparative functional analysis of a new CDR1-like ABC transporter gene in multidrug resistance and virulence between Magnaporthe oryzae and Trichophyton mentagrophytes
作者：Wang, Jing;Xiao, Chenwen;Liang, Shuang;Noman, Muhammad;Cai, Yingying;Zhang, Zhen;Zhu, Xueming;Chai, Rongyao;Qiu, Haiping;Hao, Zhongna;Wang, Yanli;Wang, Jiaoyu;Sun, Guochang;Lin, Fucheng;Bao, Guolian
关键词：
MoCDR1 ;TmCDR1 ; ABC transporters;Magnaporthe oryzae ;Trichophyton mentagrophytes -
A Study on Real-Time Detection of Rice Diseases in Farmlands Based on Multidimensional Data Fusion
作者：Ye, Wei;Ye, Wei;Jiang, Fei;Li, Zhaoxing;Zhao, Lei;Jiang, Fei;Wang, Jiaoyu;Wang, Hongkai
关键词：attention mechanism; deep learning; multidimensional feature fusion; object detection; YOLOv5
