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Investigating the metabolism of four sulfonamides in grass carp via HPLC-MS for screening candidate materials of matrix reference material

文献类型： 外文期刊

作者： Zhang, Chaoying 1 ; Niu, Bingjie 1 ; Fang, Jianhui 1 ; Mu, Yingchun 1 ; Li, Jincheng 1 ; Liu, Huan 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Dept Qual & Safety, Beijing 100141, Peoples R China

2.Chinese Acad Fishery Sci, Key Lab Control Qual & Safety Aquat Prod, Minist Agr & Rural Affairs, Beijing 100141, Peoples R China

3.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China

关键词： Pharmacokinetics; Antibiotics; Quality control; Candidate materials; Matrix reference materials

期刊名称：FOOD CHEMISTRY （ 影响因子：9.8； 五年影响因子：9.7 ）

ISSN： 0308-8146

年卷期： 2025 年 464 卷

页码：

收录情况： SCI

摘要： An efficient, sensitive, and precise method for investigating the metabolism of four sulfonamides in grass carp has been established using high-performance liquid chromatography-mass spectrometry. By optimizing the experimental conditions, the method achieved a coefficient of determination above 0.999, with detection and quantification limits set at 0.5 mu g/kg and 1.0 mu g/kg, respectively. Recovery rates were between 92.90 % and 102.84 %, and relative standard deviations ranged from 1.70 % to 9.83 %, enabling the precise detection of these sulfonamides in grass carp tissue. The factors affecting the metabolic rate during the medicated bath process were investigated, and obtained the optimal parameter conditions for screening the candidate materials. The candidate materials screened through this method exhibit good stability when used to prepare matrix standard substances, this work not only provides a scientific basis for screening sulfonamide candidate materials but also offers insights for developing other matrix reference materials.

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