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Integrated metabolomics and lipidomics analyses suggest the temperature-dependent lipid desaturation promotes aflatoxin biosynthesis in Aspergillus flavus

文献类型： 外文期刊

作者： Wu, Shaowen 1 ; Huang, Wenjie 1 ; Wang, Fenghua 1 ; Zou, Xinlu 1 ; Li, Xuan 1 ; Liu, Chun-Ming 2 ; Zhang, Wenyang 1 ; Yan, Shijuan 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangdong Key Lab Crop Germplasm Resources Preserv, Guangzhou, Peoples R China

2.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing, Peoples R China

关键词： Aspergillus flavus; aflatoxins; metabolomics; lipidomics; temperature

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）

ISSN：

年卷期： 2023 年 14 卷

页码：

收录情况： SCI

摘要： Temperature is one of the main factors affecting aflatoxin (AF) biosynthesis in Aspergillus flavus. Previous studies showed that AF biosynthesis is elevated in A. flavus at temperatures between 28 degrees C-30 degrees C, while it is inhibited at temperatures above 30 degrees C. However, little is known about the metabolic mechanism underlying temperature-regulated AF biosynthesis. In this study, we integrated metabolomic and lipidomic analyses to investigate the endogenous metabolism of A. flavus across 6 days of mycelia growth at 28 degrees C (optimal AF production) and 37 degrees C (no AF production). Results showed that both metabolite and lipid profiles were significantly altered at different temperatures. In particular, metabolites involved in carbohydrate and amino acid metabolism were up-regulated at 37 degrees C on the second day but down-regulated from days three to six. Moreover, lipidomics and targeted fatty acids analyses of mycelia samples revealed a distinct pattern of lipid species and free fatty acids desaturation. High degrees of polyunsaturation of most lipid species at 28 degrees C were positively correlated with AF production. These results provide new insights into the underlying metabolic changes in A. flavus under temperature stress.

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