文献类型： 外文期刊
作者： Yang, Shuo 1 ; Ma, Hong 2 ; Wang, Liang 2 ; Wang, Fang 2 ; Xia, Jiqiao 3 ; Liu, Dongyu 4 ; Mu, Linlin 5 ; Yang, Xiuqin 1 ; Liu, Di 2 ;
作者机构： 1.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin 150030, Peoples R China
2.Heilongjiang Acad Agr Sci, Inst Anim Husb, Harbin 150086, Peoples R China
3.Hebei Normal Univ Sci & Technol, Coll Anim Sci & Technol, Qinhuangdao 066004, Peoples R China
4.Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Daqing 163319, Peoples R China
5.Heilongjiang Acad Agr Sci, Inst Forage & Grassland Sci, Harbin 150086, Peoples R China
关键词： cold stress; piglets; ADRB3; beige adipocytes; thermogenesis
期刊名称：CELLS （ 影响因子：6.0； 五年影响因子：6.7 ）
ISSN：
年卷期： 2024 年 13 卷 8 期
页码：
收录情况： SCI
摘要： After exposure to cold stress, animals enhance the production of beige adipocytes and expedite thermogenesis, leading to improved metabolic health. Although brown adipose tissue in rodents is primarily induced by beta 3-adrenergic receptor (ADRB3) stimulation, the activation of major beta-adrenergic receptors (ADRBs) in pigs has been a topic of debate. To address this, we developed overexpression vectors for ADRB1, ADRB2, and ADRB3 and silenced the expression of these receptors to observe their effects on the adipogenic differentiation stages of porcine preadipocytes. Our investigation revealed that cold stress triggers the transformation of subcutaneous white adipose tissue to beige adipose tissue in pigs by modulating adrenergic receptor levels. Meanwhile, we found that ADRB3 promotes the transformation of white adipocytes into beige adipocytes. Notably, ADRB3 enhances the expression of beige adipose tissue marker genes, consequently influencing cellular respiration and metabolism by regulating lipolysis and mitochondrial expression. Therefore, ADRB3 may serve as a pivotal gene in animal husbandry and contribute to the improvement of cold intolerance in piglets.
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