A comparative proteomic-based study identifies essential factors involved in hair follicle growth in inner Mongolia cashmere goats
文献类型： 外文期刊
作者： Nai, Rile 1 ; Zhang, Chongyan 1 ; Xie, Yuchun 5 ; Man, Duhu 2 ; Li, Haijun 6 ; Ma, Lina 1 ; Mi, Lu 1 ; Zhao, Meng 8 ; Mu, Qier 1 ; Gao, Lixia 9 ; Liu, Zhihong 1 ; Li, Jinquan 1 ;
作者机构： 1.Inner Mongolia Agr Univ, Coll Anim Sci, Hohhot 010018, Peoples R China
2.Hulunbuir Univ, Coll Agr, Hulunbuir 021008, Peoples R China
3.Inner Mongolia Key Lab Sheep & Goat Genet Breeding, Hohhot 010018, Peoples R China
4.Minist Agr, Key Lab Sheep & Goat Genet & Breeding, Hohhot 010018, Peoples R China
5.Hebei Normal Univ Sci & Technol, Coll Anim Sci & Technol, Qinhuangdao 066004, Peoples R China
6.Inner Mongolia Agr Univ, Coll Vet Med, Hohhot 010018, Peoples R China
7.Inner Mongolia Fengxin Pharmaceut Co Ltd, Hohhot 010010, Peoples R China
8.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010018, Peoples R China
9.Baotou Light Ind Vocat Tech Coll, Baotou 014035, Peoples R China
关键词： Cashmere goat; Proteomics; Hair follicle; Telogen; Anagen
期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.6； 五年影响因子：2.7 ）
ISSN：
年卷期： 2025 年 21 卷 1 期
页码：
收录情况： SCI
摘要： Renowned for its invaluable undercoat, the cashmere goat is well known. The growth of cashmere fibre initiates when the relatively inactive telogen stage transitions to the anagen stage, which involves active proliferation. However, the molecular mechanisms responsible for this process are still unclear. Here, SWATH mass spectrometry (MS), a comparative proteomic analysis, was conducted to examine the proteomic alterations in Inner Mongolia cashmere goat skin samples at two different developmental stages (anagen and telogen). In total, 2414 proteins were detected, with 631 proteins showing differential regulation (503 upregulated proteins and 128 downregulated proteins). Bioinformatic analysis revealed that these proteins, which are differentially regulated, play crucial roles in the pathways associated with metabolism and fatty acids according to the GO and KEGG analyses. Furthermore, interactome analysis revealed that differentially regulated keratins have a crucial impact. The localization of KRT25, KRT71, and KRT82 using immunohistochemistry revealed that these proteins were expressed in the secondary hair follicles of cashmere goat skin. The keratin family plays an irreplaceable and important role in the process of hair follicle growth.
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