Immunomodulatory activity of a water-soluble polysaccharide extracted from mussel on cyclophosphamide-induced immunosuppressive mice models
文献类型： 外文期刊
作者： Xiang, Xingwei 1 ; Wang, Rui 1 ; Chen, Lin 5 ; Chen, Yufeng 1 ; Zheng, Bin 6 ; Deng, Shanggui 6 ; Liu, Shulai 1 ; Sun, Peilong 1 ; Shen, Guoxin 5 ;
作者机构： 1.Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Zhejiang, Peoples R China
2.Key Lab Marine Fishery Resources Exploitment Util, Hangzhou 310014, Peoples R China
3.Natl R&D Branch Ctr Pelag Aquat Prod Proc Hangzho, Hangzhou 310014, Peoples R China
4.Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China
5.Zhejiang Acad Agr Sci, Sericultural & Tea Inst, Hangzhou 310021, Zhejiang, Peoples R China
6.Zhejiang Ocean Univ, Food & Pharm Coll, Zhoushan 316000, Zhejiang, Peoples R China
期刊名称：NPJ SCIENCE OF FOOD （ 影响因子：7.0； 五年影响因子：9.657 ）
ISSN：
年卷期： 2022 年 6 卷 1 期
页码：
收录情况： SCI
摘要： This study aimed to investigate the protective effect of mussel polysaccharide (MP) on cyclophosphamide (Cy)-induced intestinal mucosal immunosuppression and microbial dysbiosis in mice. MP was shown to stimulate secretion of cytokines (SIgA, IL-2, IF-gamma, IL-4, IL-10) and production of transcription factors (occludin, claudin-1, ZO-1, mucin-2, IL-2, IF-gamma, IL-4, IL-10). Key proteins (p-I kappa B-alpha, p-p65) of the NF-kappa B pathway were upregulated after MP administration. SCFAs levels, which were decreased after the Cy treatment, were improved after treatment with MP. Furthermore, 16 S rRNA sequencing data of fecal samples revealed, through alpha-diversity and beta-diversity analysis, that MP improved microbial community diversity and modulate the overall composition of gut microbiota. Taxonomic composition analysis showed that MP increased the abundance of probiotics species (Lactobacillus) and decreased the proportion of pathogenic species (Desulfovibrio). These findings suggested that MP has a potential immunomodulatory activity on the immunosuppressive mice.
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