Sub-chronically exposing zebrafish to environmental levels of methomyl induces dysbiosis and dysfunction of the gut microbiota
文献类型： 外文期刊
作者： Li, Mingxiao 1 ; Chen, Xi 1 ; Song, Chao 1 ; Fan, Limin 1 ; Qiu, Liping 2 ; Li, Dandan 2 ; Xu, Huimin 2 ; Meng, Shunlong 1 ; Mu, Xiyan 3 ; Xia, Bin 4 ; Ling, Jun 5 ;
作者机构： 1.Nanjing Agr Univ, Wuxi Fishery Coll, Wuxi 214081, Peoples R China
2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Sci Observing & Expt Stn Fishery Resources & Envir, Wuxi 214081, Peoples R China
3.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Beijing 100081, Peoples R China
4.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China
5.Anhui Acad Agr Sci, Fisheries Inst, Hefei 230031, Peoples R China
关键词： Methomyl; 16S rRNA; Metabolism; Inflammation; Apoptosis; Danio rerio
期刊名称：ENVIRONMENTAL RESEARCH （ 影响因子：7.7； 五年影响因子：7.5 ）
ISSN： 0013-9351
年卷期： 2024 年 261 卷
页码：
收录情况： SCI
摘要： The widespread use of carbamate pesticides has led to numerous environmental and health concerns, including water contamination and perturbation of endocrine homeostasis among organisms. However, there remains a paucity of research elucidating the specific effects of methomyl on gut microbial composition and physiological functions. This study aimed to investigate the intricate relationship between changes in zebrafish bacterial communities and intestinal function after 56 days of sub-chronic methomyl exposure at environmentally relevant concentrations (0, 0.05, 0.10, and 0.20 mg/L). Our findings reveal significant methomyl-induced morphological changes in zebrafish intestines, characterized by villi shortening and breakage. Notably, methomyl exposure down-regulated nutrient and energy metabolism, and drug metabolism at 0.05-0.10 mg/L, while up-regulating cortisol, inflammation-related genes, and apoptotic markers at 0.20 mg/L. These manifestations indicate physiological stress imposition and disruption of gut microbiota equilibrium, impacting metabolic processes and instigating low-grade inflammatory responses and apoptotic cascades. Importantly, changes in intestinal function significantly correlated with shifts in specific bacterial taxa abundance, including Shewanella, Rubrobacter, Acinetobacter, Bacillus, Luteolibacter, Nocardia, Defluviimonas, and Bacteroides genus. In summary, our study underscores the potential adverse effects of environmental methomyl exposure on aquatic organisms, emphasizing the necessity for further research to mitigate its repercussions on environmental health and ecosystem stability.
- 相关文献
作者其他论文 更多>>
-
Comparison of toxic effects of phenanthrene and perfluorooctane sulfonate on Chinese tongue sole Cynoglossus semilaevis larva in a muti-biomarker approach
作者：Zhang, Zhe;Duan, Yafei;Zhang, Linbao;Tian, Fei;Xiong, Qian;Chen, Haigang;Xia, Bin
关键词：Cynoglossus semilaevis; Phenanthrene; Perfluorooctane sulfonate; Cytochrome P450; Antioxidant enzymes; Nuclear hormone receptor
-
Latex microspheres lateral flow immunoassay with smartphone-based device for rapid detection of Cryptococcus
作者：Zang, Xuelei;Zhou, Yangyu;Zang, Xuefeng;Lin, Xuwen;Deng, Hui;Huang, Yemei;Xue, Xinying;Zang, Xuelei;Deng, Hengyu;Xue, Xinying;Li, Shuming;Shi, Gang;Wu, Lidong;Cao, Jingrong;Yang, Ruonan;Yang, Chen;Wu, Ningxin;Song, Chao
关键词：
-
Flux profile of selenium intake and dietary health assessment of tilapia products in China e-commerce platform
作者：Jing, Zhenyi;Guan, Ziqiang;Yin, Qianyue;Wang, Changbo;Fan, Limin;Meng, Shunlong;Song, Chao;Guan, Ziqiang;Fang, Longxiang;Yin, Qianyue;Wang, Changbo;Fan, Limin;Meng, Shunlong;Song, Chao;Fang, Longxiang;Wang, Changbo;Fan, Limin;Meng, Shunlong;Song, Chao;Fang, Longxiang;Wang, Changbo;Fan, Limin;Meng, Shunlong;Song, Chao;Fang, Longxiang;Wang, Changbo;Fan, Limin;Meng, Shunlong
关键词：Selenium; Tilapia; Sales Patterns; Product Forms; Dietary Health Impact Assessment
-
Magnetic nanoparticle modified moss Biochar: A novel solution for effective removal of enrofloxacin from aquaculture water
作者：Li, Zhonghua;Pitakrattanawong, Chompoonuch;Zhu, Lei;Fan, Limin;Song, Chao;Fang, Longxiang;Fan, Limin;Song, Chao;Meng, Shunlong;Fang, Longxiang;Fan, Limin;Song, Chao;Meng, Shunlong;Fang, Longxiang;Fan, Limin;Song, Chao;Meng, Shunlong;Fang, Longxiang;Fan, Limin;Song, Chao;Meng, Shunlong;Song, Chao;Meng, Shunlong
关键词：Resource recycling; Enrofloxacin; Magnetic biochar; Adsorption mechanism
-
Occurrence, trophic transfer and risk assessment of microplastics in fishery organisms from the Bohai Sea, China
作者：Li, Qilong;Zhu, Lin;Pu, Xiaoying;Sui, Qi;Sun, Xuemei;Zhao, Xinguo;Xia, Bin;Zhu, Lin;Sui, Qi;Sun, Xuemei;Zhao, Xinguo;Xia, Bin;Wang, Rongyuan
关键词：Microplastics; Marine food chain; Influencing factors; Trophic transfer; Risk assessment
-
Functionalization-dependent toxicity of MIL-101 metal-organic frameworks to phytoplankton Chlamydomonas reinhardtii
作者：Wang, Meiyu;Xia, Bin;Cui, Zhengguo;Qu, Keming;Li, Yiling;Wang, Meiyu
关键词：MIL-101 metal organic frameworks; Chlamydomonas reinhardtii; Toxicity; Metabolism
-
Potential impact of marine-derived plastisphere as a Vibrio carrier on marine ecosystems: Current status and future perspectives
作者：Sun, Xuemei;Sui, Qi;Zhu, Lin;Yu, Yongxiang;Xia, Bin;Sun, Xuemei;Sui, Qi;Zhu, Lin;Xia, Bin;Booth, Andy M.;Meng, Shunlong;Xing, Baoshan
关键词：Microplastics; Biofilm; Vibrio; Mariculture; Biogeochemical cycling; Pathogen dispersal
