Remedial effects of tilapia skin peptides against dexamethasone-induced muscle atrophy in mice by modulation of AKT/FOXO3a and Sirt1/PGC-1α signaling pathways
文献类型： 外文期刊
作者： Lin, Cuixian 1 ; Zeng, Jian 1 ; Zhang, Shilin 1 ; Xu, Xiaolan 1 ; Chen, Lang 3 ; Yang, Zhiyou 1 ; Wu, Wenjin 3 ; Hu, Chuanyin 2 ; Zhao, Yun-Tao 1 ;
作者机构： 1.Guangdong Ocean Univ, Coll Food Sci & Technol, Modern Biochem Expt Ctr,Guangdong Prov Key Lab Aqu, Guangdong Prov Engn Lab Marine Biol Prod, Zhanjiang 524088, Peoples R China
2.Guangdong Med Univ, Dept Biol, Zhanjiang 524023, Peoples R China
3.Hubei Acad Agr Sci, Inst Agr Prod Proc & Nucl Agr Technol, Key Lab Agr Prod Cold Chain Logist, Minist Agr & Rural Affairs, Wuhan 430064, Peoples R China
4.Guangdong Ocean Univ, Coll Food Sci & Technol, 1 Hai Da Rd, Zhanjiang 524088, Peoples R China
关键词： Tilapia skin peptides; Dexamethasone; Muscle atrophy; AKT/FOXO3a; Sirt1/PGC-1 alpha
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）
ISSN： 1756-4646
年卷期： 2024 年 113 卷
页码：
收录情况： SCI
摘要： Tilapia skin peptides (TSP) possess a range of physiological activities. This study aimed to explore the effects of TSP on Dexamethasone (DEX)-induced muscle atrophy. In vitro, C2C12 myotube myotube diameter and expression levels of the muscle-specific E3 ubiquitin ligases F -box only protein 32 (Atrogin-1) and muscle ring finger protein 1 (MuRF1) challenged with DEX were reversed by TSP. In vivo, DEX was injected subcutaneously to build muscle atrophy model mice. TSP enhanced grip strength, running distance, body lean muscle content, cross-sectional area of the gastrocnemius and tibialis anterior muscles of DEX-induced mice. Moreover, TSP inhibited the expression levels of Atrogin-1 and MuRF1. Mechanically, TSP improved DEX-induced muscle atrophy by regulating the Protein Kinase B alpha (AKT)/Forkhead box O3 protein (FOXO3a), Sirtuin 1 (Sirt1)/ peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) signaling pathway, and downstream factors such as nuclear respiratory factor (NRF)1/2 and mitochondrial transcription factor A (TFAM).
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