文献类型： 外文期刊

作者： Lin, Z ¹ ; Ping, Z ² ; Kong, D ³ ; Yin, K ⁴ ; Cai, Z ⁵ ;

作者机构： 1.Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Trop Marine Environm Dynam, Guangzhou 510301, Peoples R China

2.Chinese Acad Fishery Sci, E China Sea Fisheries Res Inst, Minist Agr, Key Lab Marine & Estuarine Fisheries, Shanghai 200090, Peoples R China

3.Jinan Univ, Inst Hydrobiol, Guangzhou 510632, Peoples R China

4.Natl Environm Protect Agcy, Nanjing Inst Environm Sci, Nanjing 210042, Peoples R China

5.Chinese Acad Sci, S China Sea Inst Oceanol, Dept Appl Marine Biol, Guangzhou 510301, Peoples R China

期刊名称：ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY （ 影响因子：2.804； 五年影响因子：3.399 ）

ISSN： 0090-4341

年卷期： 2005 年 49 卷 1 期

页码：

收录情况： SCI

摘要： A new hypothesis, the Climax Hypothesis, is proposed to describe how the ratios of individual chemicals influence the joint effects of chemical mixtures. This hypothesis is derived from a generalized approach using "isobolograms." With this hypothesis, one can predict that for a given mixture, a curvilinear correlation exists between the joint effects and the ratios of individual chemicals and that this curve has a climax at the equitoxic ratio. This prediction is supported by the observed toxicity to Vibrio fischeri of 18 mixtures (12 binary mixtures, 4 ternary mixtures, and 2 quaternary mixtures). With this prediction, the Climax Hypothesis has some promising applications such as controlling the discharge of effluents in environmental science, maximizing detoxifying effects in medicine, and optimizing combined pesticides in agriculture.