文献类型： 外文期刊
作者： Xu, CX 1 ; Wang, SY 2 ; Zhang, ZX 2 ; Peng, XX 2 ;
作者机构： 1.Xiamen Univ, Sch Life Sci, Dept Biol, Xiamen 361005, Fujian, Peoples R China
2.Xiamen Univ, Sch Life Sci, Dept Biol, Xiamen 361005, Fujian, Peoples R China; Xiamen Univ, Dept Oceanog, Xiamen 361005, Fujian, Peoples R China; Chinese Acad Fishery Sci, E China Sea Fisheries Res Inst, Minist Agr, Key Lab Marine & Estuarine Fisheries, Shanghai 20009, Peoples R China
关键词： bacteria;antigenic cross-reactivity;outer membrane proteins;cluster analysis
期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.932； 五年影响因子：4.624 ）
ISSN： 1567-5769
年卷期： 2005 年 5 卷 7-8 期
页码：
收录情况： SCI
摘要： In the present study, antigenic cross-reactivity of OMPs was investigated in several species of bacterial pathogens. Heterogeneous mouse or fish antisera were used to ascertain OMPs with cross-reactivity and cluster analysis was performed to analyze the distribution of cross-antigenic OMPs in diverse bacterial strains. We interestingly found that eleven and seven bands could be reacted with four kinds of heterogeneous mouse and fish antisera, respectively, and the phenograms constructed could provide ideal targeted bacteria for candidate genes of polyvalent vaccines. Importantly, there were significant differences in reaction with bacteria between mouse and fish antisera, but commonly antigenic bands still existed between them. Our results suggest that the cross-reactivity of OMPs exists commonly in Gram-negative bacteria, which may be a promising choice for the development of polyvalent OMP vaccines. Meanwhile, cluster analysis will help to understand the relation of cross-antigenic OMPs among Gram-negative bacteria. (C) 2005 Elsevier B.V. All rights reserved.
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