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Photoprotective effects of sweet potato leaf polyphenols and caffeic acid against UV-induced skin-damage in BALB/C nude mice

文献类型： 外文期刊

作者： Hong, Jingyang 1 ; Mu, Taihua 1 ; Sun, Hongnan 1 ; Blecker, Christophe 2 ; Richel, Aurore 3 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Food Sci & Technol, Lab Food Chem & Nutr Sci, Key Lab Agroprod Proc,Minist Agr & Rural Affairs, 2 Yuan Ming Yuan West Rd,POB 5109, Beijing 100193, Peoples R China

2.Univ Liege, Gembloux Agrobio Tech, Dept Food Sci & Formulat, Passage Deportes 2, Gembloux, Belgium

3.Univ Liege, Gembloux Agrobio Tech, Biol & Ind Chem Unit, Passage Deportes 2, B-5030 Gembloux, Belgium

期刊名称：FOOD & FUNCTION （ 影响因子：6.317； 五年影响因子：6.375 ）

ISSN： 2042-6496

年卷期： 2022 年 13 卷 13 期

页码：

收录情况： SCI

摘要： This study aimed at clarifying the mechanism by which sweet potato leaf polyphenols (SPLPs) ameliorate ultraviolet (UV) radiation damage, using the BALB/c hairless female mouse model. The moisture and hydroxyproline (HYP) contents of the model mouse skin and the thickness of the epidermis and dermis were determined by staining and histological examination. Anti-oxidative enzyme activities, malondialdehyde (MDA) content, and protein carbonyl content in skin tissue and serum were investigated. Expression of inflammatory markers and mitogen-activated protein kinase signaling pathways were evaluated. Topical caffeic acid at 30 mg kg(-1) most strongly inhibited the decrease in skin moisture, HYP content, and the thickening of the epidermis. Topical SPLP at 100 mg kg(-1) most significantly inhibited the dermal thickening, increased the activities of the superoxide dismutase, catalase as well as glutathione peroxidase, and decreased the content of serum MDA and protein carbonyls markedly. Furthermore, the topical SPLP suppressed the UV-induced rise in the inflammatory markers MMP-1, TNF-alpha, and NF-kappa B, and alleviated phosphorylation levels of the stress-signaling proteins JNK and p38. Thus, topical SPLP provided the best overall protection for mouse skin from UV-induced damage.

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