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Uncovering hidden dangers: The combined toxicity of abamectin and lambda-cyhalothrin on honey bees

文献类型： 外文期刊

作者： Chen, Xiaozhen 1 ; Wang, Feidi 2 ; Guo, Haikun 2 ; Liu, Xinju 2 ; Wu, Shenggan 2 ; Lv, Lu 2 ; Tang, Tao 2 ;

作者机构： 1.Ningbo Univ, Coll Food Sci & Engn, Ningbo 315800, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Pesticide Residue Detect Minist Agr & Rura, Hangzhou 310021, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, 198 Shiqiao Rd, Hangzhou 310021, Peoples R China

关键词： Honey bees; Insecticides; Combined toxicity; Gut microbiota; Immune system; Detoxification

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）

ISSN： 0048-9697

年卷期： 2024 年 933 卷

页码：

收录情况： SCI

摘要： Studying the toxic effects of pesticides on bees has consistently been a prominent area of interest for researchers. Nonetheless, existing research has predominantly concentrated on individual toxicity assessments, leaving a gap in our understanding of mixed toxicity. This study delves into the individual and combined toxic effects of abamectin (ABA) and lambda-cyhalothrin (LCY) on honey bees ( Apis mellifera ) in laboratory settings. We discovered that ABA (96 h-LC 50 value of 0.079 mg/L) exhibited greater acute toxicity to honey bees compared to LCY (96 h-LC 50 value of 9.177 mg/L). Moreover, the mixture of ABA and LCY presented an acute antagonistic effect on honey bees. Additionally, our results indicated that exposure to LCY, at medium concentration, led to a reduction in the abundance of gut core bacterium Snodgrassella . However, an increase in the abundance of Bifidobacterium was noted when exposed to a medium concentration of LCY and its mixture with ABA. Transcriptomic analysis revealed significant regulation of certain genes in the medium concentration of all three treatments compared to the control group, primarily enriching in metabolism and immune-related pathways. Following chronic exposure to field-relevant concentrations of ABA, LCY, and their mixture, there were significant alterations in the activities of immunity-related enzyme polyphenol oxidase (PPO) and detoxification enzymes glutathione S-transferase (GST) and carboxylesterase (CarE). Additionally, the expression of four genes ( abaecin , cyp9e2 , cyp302a1 , and GstD1 ) associated with immune and detoxification metabolism was significantly altered. These findings suggest a potential health risk posed by the insecticides ABA and LCY to honey bees. Despite exhibiting acute antagonistic effect, mixed exposure still induced damage to bees at all levels. This study advances our knowledge of the potential adverse effects of individual or combined exposure to these two pesticides on non -target pollinators and offers crucial guidance for the use of insecticides in agricultural production.

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