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Effects of microcystin-LR on behavior, histopathology, oxidative stress, non-specific immunity and gene expression of red claw crayfish (Cherax quadricarinatus)

文献类型： 外文期刊

作者： Lu, Yao-Peng 1 ; Zhang, Xiu-Xia 1 ; Zheng, Pei-Hua 1 ; Li, Jun-Tao 1 ; Li, Jia-Jun 1 ; Li, Teng 1 ; Wang, Xiao 1 ; Wang, Dong -Mei 1 ; Xian, Jian-An 1 ; Zhang, Ze -Long 1 ; Wang, An-Li 3 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliza, Haikou 571101, Peoples R China

2.Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Peoples R China

3.South China Normal Univ, Sch Life Sci, Guangzhou 510631, Peoples R China

关键词： Cherax quadricarinatus; Microcystin-LR; Oxidative stress; Non-specific immunity; Gene expression

期刊名称：AQUACULTURE REPORTS （ 影响因子：3.7； 五年影响因子：3.8 ）

ISSN： 2352-5134

年卷期： 2023 年 33 卷

页码：

收录情况： SCI

摘要： Microcystin-LR (MC-LR), the most prevalent cyanobacterial toxin, poses a serious threat to the survival of aquatic animals. Herein, crayfish (Cherax quadricarinatus) were treated with MC-LR at 33.06 mu g kg-1 for 48 h, and the effects of MC-LR on behavior, histomorphology, oxidative stress, non-specific immunity, and gene expression were investigated to elucidate the molecular mechanisms underlying antioxidation and detoxification in crayfish. MC-LR caused vacuolation and disruption of crayfish hepatopancreatic cells, although no significant effect was observed on the structure of intestinal cells. Moreover, MC-LR increased the activity of antioxidant enzymes (SOD, CAT, GPx, GST) and up-regulated the expression of genes encoding antioxidant enzymes (ecCu,Zn-SOD, SOD, Se-GPx, GPx3P, GST). In addition, GSH was found depleted in the hepatopancreas and plasma. MC-LR activated the immune system, enhanced immunoenzyme activity (ACP, AKP) and induced the expression of immunity-related genes (C-LZM, proPO, hemocyanin). Furthermore, caspase and HSP70 genes were induced in the hepatopancreas of crayfish under MC-LR stress. Taken together, MC-LR was shown to cause a positive response in crayfish, and our findings suggested that the antioxidant activity and immune system play an important role in protecting crayfish from MC-LR stress by regulating gene expression and activities of antiox-idant and immune enzymes.

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