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In vitro digestion under simulated saliva, gastric and small intestinal conditions and fermentation by human gut microbiota of polysaccharides from the fruits of Lycium barbarum

文献类型: 外文期刊

作者: Ding, Yu 1 ; Yan, Yamei 2 ; Peng, Yujia 1 ; Chen, Dan 1 ; Mi, Jia 2 ; Lu, Lu 2 ; Luo, Qing 2 ; Li, Xiaoying 2 ; Zeng, Xiaoxiong 1 ; Cao, Youlong 2 ;

作者机构: 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China

2.Natl Wolfberry Engn Res Ctr, Yinchuan 750002, Peoples R China

关键词: Lycium barbarum; Polysaccharides; Digestion; Fermentation; Gut microbiota

期刊名称:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES ( 影响因子:8.025; 五年影响因子:7.626 )

ISSN: 0141-8130

年卷期: 2019 年 125 卷

页码:

收录情况: SCI

摘要: In the present study, the digestion under simulated saliva, gastric and small intestinal conditions and in vitro fermentation by human gut microbiota of Lycium barbarum polysaccharides (LBPS) were investigated. As a result, LBPS contained carbohydrates, uronic acids, protein and polyphenols of 60.96 +/- 5.58, 20.98 +/- 2.49, 5.30 +/- 0.12 and 1.04 +/- 0.06%, respectively. Furthermore, LBPS was mainly consisted of glucuronic acid (5.12 mol%), galacturonic acid (12.40 mol%), glucose (2.15 mol%), galactose (39.67 mol%) and arabinose (40.66 mol%). Under simulated saliva, gastric and small intestinal conditions, LBPS was not affected. Whereas, LBPS could be utilized by gut microbiota based on the consumption of monosaccharides, decreased molecular weight and lower content of total carbohydrates after fermentation in vitro. With the proceeding of fermentation, LBPS significantly promoted the production of short-chain fatty acids. Meanwhile, LBPS could alter the microbial community after 24 h fermentation, especially enhancing the relative abundances of genera Bacteroides, Bifidobacterium, Phascolarctobacterium, Clostridium XlVb, Prevotella and Collinsella. All the results suggested that LBPS could be developed as special ingredients for modulating gut microbiota composition and promoting the growth of beneficial bacteria like Bifidobacterium. (C) 2018 Elsevier B.V. All rights reserved.

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