Multispecies probiotics complex improves bile acids and gut microbiota metabolism status in an in vitro fermentation model
文献类型： 外文期刊
作者： Liu, Wei 1 ; Li, Zhongxia 2 ; Ze, Xiaolei 2 ; Deng, Chaoming 2 ; Xu, Shunfu 3 ; Ye, Feng 3 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou, Peoples R China
2.BYHEALTH Inst Nutr & Hlth, Guangzhou, Peoples R China
3.Nanjing Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Nanjing, Peoples R China
关键词： Bile acids; gut microbiota; metabolism; probiotics; in vitro fermentation model
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：4.0； 五年影响因子：5.1 ）
ISSN：
年卷期： 2024 年 15 卷
页码：
收录情况： SCI
摘要： The consumption of probiotics has been extensively employed for the management or prevention of gastrointestinal disorders by modifying the gut microbiota and changing metabolites. Nevertheless, the probiotic-mediated regulation of host metabolism through the metabolism of bile acids (BAs) remains inadequately comprehended. The gut-liver axis has received more attention in recent years due to its association with BA metabolism. The objective of this research was to examine the changes in BAs and gut microbiota using an in vitro fermentation model. The metabolism and regulation of gut microbiota by commercial probiotics complex containing various species such as Lactobacillus, Bifidobacterium, and Streptococcus were investigated. The findings indicated that the probiotic strains had produced diverse metabolic profiles of BAs. The probiotics mixture demonstrated the greatest capacity for Bile salt hydrolase (BSH) deconjugation and 7 alpha-dehydroxylation, leading to a significant elevation in the concentrations of Chenodeoxycholic acid, Deoxycholic acidcholic acid, and hyocholic acid in humans. In addition, the probiotic mixtures have the potential to regulate the microbiome of the human intestines, resulting in a reduction of isobutyric acid, isovaleric acid, hydrogen sulfide, and ammonia. The probiotics complex intervention group showed a significant increase in the quantities of Lactobacillus and Bifidobacterium strains, in comparison to the control group. Hence, the use of probiotics complex to alter gut bacteria and enhance the conversion of BAs could be a promising approach to mitigate metabolic disorders in individuals.
- 相关文献
作者其他论文 更多>>
-
Chitosan oligosaccharide improves intestinal homeostasis to achieve the protection for the epithelial barrier of female Drosophila melanogaster via regulating intestinal microflora
作者：Wang, Lu;Zhang, Cheng;Fan, Shuhang;Zhou, Weihao;Zhou, Zhaohui;Liu, Yuhang;Wang, Qianna;Dai, Xianjun;Wang, Jianfeng;Liu, Wei;Dai, Xianjun
关键词：chitosan oligosaccharide; Drosophila melanogaster; oxidant stress; intestinal homeostasis; intestinal microflora
-
Bacterial, short-chain fatty acid and gas profiles of partially hydrolyzed guar gum in vitro fermentation by human fecal microbiota
作者：Pi, Xiong-E;Fu, Hao;Quan, Hui Hui;Lu, Li-Zhi;Liu, Wei;Yang, Xiao-Xia;Yu, Zai-Chun;Zhang, Yinjun;Teng, Wei-Lin;Ye, Xue-Wei
关键词：Partially hydrolyzed guar gum; Gas production; SCFAs; Gut microbiota
-
Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer
作者：Jia, Dingjiacheng;Qi, Yadong;Jiang, Yao;Lin, Yifeng;Sun, Yong;Chen, Wenwen;Fan, Lina;Xu, Chaochao;Ge, Qiwei;Xu, Fei;Wang, Liangjing;Jia, Dingjiacheng;Wang, Qiwen;Qi, Yadong;Jiang, Yao;He, Jiamin;Lin, Yifeng;Sun, Yong;Xu, Jilei;Chen, Wenwen;Fan, Lina;Yan, Ruochen;Xu, Chaochao;Ge, Qiwei;Wang, Lan;Chen, Shujie;Wang, Liangjing;Wang, Qiwen;He, Jiamin;Xu, Jilei;Yan, Ruochen;Wang, Lan;Chen, Shujie;Chen, Shujie;Wang, Liangjing;Zhang, Wang;Ren, Guohong;Liu, Wei;Xu, Fei;Wu, Pin;Wang, Yuhao
关键词：
-
Modulation Mechanism of Wuniuzao Dark Tea Polysaccharide on Lipid Metabolism in Hyperlipidemic Mice Induced by High-Fat Diet
作者：Zou, Xuanxuan;Dong, Zonghua;Zhao, Jin;Guan, Feng;Ge, Jian;Liu, Wei
关键词：Wuniuzao dark tea polysaccharide; Lipid metabolism; Gut microbiota; Serum exosome
-
Characterization of Various Noncovalent Polyphenol-Starch Complexes and Their Prebiotic Activities during In Vitro Digestion and Fermentation
作者：Cai, Ming;Feng, Jicai;Wang, Jian;Chen, Peng;Sun, Peilong;Cai, Ming;Feng, Jicai;Wang, Jian;Chen, Peng;Sun, Peilong;Ge, Zhiwei;Liu, Wei;Wu, Liehong;Wu, Jianyong
关键词：polyphenol-starch complex; noncovalentinteraction; in vitro digestion; prebiotic activity; in vitro fermentation
-
Exploring the mechanism of probiotics in enhancing the utilization of chemical components (or polyphenols) of grape seed extract
作者：Xu, Lei;Li, Xiaoqiong;Zhu, Liying;Wang, Xin;Li, Jinjun;Xu, Lei;Sun, Haibiao;Liao, Jiahao;Xu, Benhong;Li, Liang;Ze, Xiaolei
关键词：In vitro fermentation; Grape seed extract; Gut microbiota; Compound probiotics; High-performance liquid chromatography; 16S rRNA sequencing
-
Methylglyoxal scavenging capacity of fiber-bound polyphenols from highland barley during colonic fermentation and its modulation on methylglyoxal-interfered gut microbiota
作者：Li, Jinxin;Zhu, Ling;Wu, Gangcheng;Zhang, Hui;Zhang, Hao;Liu, Wei;Yang, Xijuan;Zhang, Hui
关键词：Bound phenolic compounds; Methylglyoxal; Gut microbiota; Colonic fermentation; Scavenging capacity
