Modulation Mechanism of Wuniuzao Dark Tea Polysaccharide on Lipid Metabolism in Hyperlipidemic Mice Induced by High-Fat Diet
文献类型： 外文期刊
作者： Zou, Xuanxuan 1 ; Dong, Zonghua 1 ; Liu, Wei 2 ; Zhao, Jin 1 ; Guan, Feng 1 ; Ge, Jian 1 ;
作者机构： 1.China Jiliang Univ, Coll Life Sci, Hangzhou 310018, Zhejiang, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Microbiol, Hangzhou 310021, Zhejiang, Peoples R China
关键词： Wuniuzao dark tea polysaccharide; Lipid metabolism; Gut microbiota; Serum exosome
期刊名称：PLANT FOODS FOR HUMAN NUTRITION （ 影响因子：4.0； 五年影响因子：4.4 ）
ISSN： 0921-9668
年卷期： 2024 年 79 卷 1 期
页码：
收录情况： SCI
摘要： The aim of this study was to investigate the functional mechanism of Wuniuzao dark tea polysaccharide (WDTP) that protect against hyperlipidemia in mice induced by high-fat diet. WDTP was extracted by hot water, isolated and purified by DEAE-52 chromatography and characterized by high-performance liquid chromatograph (HPLC), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM). Different doses (200 or 800 mg/kg/day) of WDTP were orally administered to mice induced by high-fat diet to evaluate the mechanism of WDTP regulating lipid metabolism. And these results showed that average molecular weight of WDTP was nearly 63,869 Da. And WDTP intervention significantly reduced body weight, lipid accumulation, and modulated blood lipid levels. The mechanism of WDTP ameliorating lipid metabolism was associated with regulating the expression of lipid metabolism-related genes and serum exosomes miR-19b-3p, and modulating the community structure of gut microbiota in mice.
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