The Liver-Protective Effects of the Essential Oil from Amomum villosum in Tilapia (Oreochromis niloticus): Antioxidant, Transcriptomic, and Metabolomic Modulations
文献类型： 外文期刊
作者： Dong, Hongbiao 1 ; Zeng, Xiangbing 1 ; Zheng, Xiaoting 1 ; Li, Chenghui 1 ; Ming, Junchao 1 ; Zhang, Jiasong 1 ;
作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploita, Minist Agr & Rural Affairs, Guangzhou 510300, Peoples R China
2.Key Lab Efficient Utilizat & Proc Marine Fishery R, Lingshui 572426, Peoples R China
3.Ocean Univ China, Key Lab Mariculture, Minist Educ, Qingdao 266003, Peoples R China
4.Zhejiang Ocean Univ, Natl Aquaculture Engn Technol Res Ctr, Zhoushan 316000, Peoples R China
关键词： tilapia; essential oil; liver protection; transcriptomics; metabolomics; diet study
期刊名称：ANTIOXIDANTS （ 影响因子：6.6； 五年影响因子：7.3 ）
ISSN：
年卷期： 2024 年 13 卷 9 期
页码：
收录情况： SCI
摘要： This study investigates the effects of the essential oil from Amomum villosum (EOA) on liver-protective effects in Nile tilapia (Oreochromis niloticus), utilizing a multidisciplinary approach that integrates physiological assessments and transcriptomic and metabolomic analyses. Fish were fed diets containing 2 g/kg of EOA over a 56-day trial, with a no-EOA diet serving as the control. The results demonstrate that EOA supplementation improves liver histology, enhances antioxidant capacities, and reduces inflammation in tilapia. The transcriptomic analysis revealed significant alterations in gene expression profiles related to RNA splicing, metabolism, and disease pathways. The identification of differential genes and disease databases identified key target genes associated with the primary component of EOA for its anti-hepatobiliary disease effects. Furthermore, a molecular docking analysis of EOA major components with core differentially expressed genes in the hepatobiliary syndrome indicated that alpha-pinene is a potential Hsp90 inhibitor, which may prevent inflammation. A metabolomic analysis further demonstrated that EOA supplementation leads to notable changes in liver phospholipids, fatty acids, and carbohydrate metabolism. These findings underscore the potential of EOA as a natural additive for improving liver health in tilapia, offering valuable insights to the aquaculture industry for enhancing fish health and welfare in intensive farming systems.
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