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Genome-wide association study of growth traits and validation of key mutations (MSTN c.C861T) associated with the muscle mass of meat pigeons

文献类型： 外文期刊

作者： Hou, Haobin 1 ; Wang, Xiaoliang 1 ; Li, Xin 1 ; Cai, Xia 1 ; Tu, Yingying 2 ; Yang, Changsuo 1 ; Yao, Junfeng 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Shanghai 201106, Peoples R China

2.Natl Poultry Engineer Res Ctr, Shanghai, Peoples R China

关键词： genome-wide association study; growth traits; MSTN; muscle mass; pigeons

期刊名称：ANIMAL GENETICS （ 影响因子：2.4； 五年影响因子：2.8 ）

ISSN： 0268-9146

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Selective breeding of meat pigeons is primarily based on growth traits, especially muscle mass (MM). Identification of functional genes and molecular markers of growth and slaughter traits through a genome-wide association study (GWAS) will help to elucidate the underlying molecular mechanisms and provide a theoretical basis for the selective breeding of meat pigeons. The phenotypic data of body weight (BW) and body size (BS) of 556 meat pigeons at 52 and 80 weeks of age were collected. In total, 160 434 high-quality single nucleotide polymorphism sites were obtained by restriction site-associated DNA sequencing. The GWAS analysis revealed that MSTN, IGF2BP3 and NCAPG/LCORL were important candidate genes affecting the growth traits of meat pigeons. IGF2BP3 and NCAPG/LCORL were highly correlated to BW and BS, which are related to overall growth and development, while MSTN was associated with pectoral thickness and BW. Phenotypic association validation with the use of two meat pigeon populations found that the MSTN mutation c.C861T determines the MM. These results provide new insights into the genetic mechanisms underlying phenotypic variations of growth traits and MM in commercial meat pigeons. The identified markers and genes provide a theoretical basis for the selective breeding of meat pigeons.

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