文献类型： 外文期刊
作者： Li, Bei 1 ; He, Xiaolong 2 ; Zhao, Yiping 1 ; Bai, Dongyi 1 ; Shiraigo, Wunierfu 1 ; Zhao, Qinan 1 ; Manglai, Dugarjav 1 ;
作者机构： 1.Inner Mongolia Agr Univ, Coll Anim Sci, Hohhot 010018, Peoples R China
2.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010031, Peoples R China
关键词： Mongolian horse;RNA-Seq;Coat color;Pigmentation;Tyrosine
期刊名称：HEREDITAS （ 影响因子：3.271； 五年影响因子：2.807 ）
ISSN： 1601-5223
年卷期： 2017 年 155 卷
页码：
收录情况： SCI
摘要： Background: Studies on the molecular genetics of horse skin pigmentation have typically focused on very few genes and proteins. In this study, we used Illumina sequencing to determine the global gene expression profiles in horses with white-colored coats and those with black-colored coats, with the goal of identifying novel genes that could regulate horse coat color. Results: Genes encoding ribosomal-associated proteins were highly expressed in horse skin. We found a total of 231 unigenes that were differentially expressed between horses with white coats and horses with black coats; 119 were down-regulated, and 112 were up-regulated. Many of the up-regulated genes in black horses, such as genes related to tyrosine metabolism, may directly regulate dark coat color. Keratin genes, MIA family genes, fatty acid-related genes, and melanoma-associated genes were also differentially regulated, which suggests that they may play important roles in coat color formation. Conclusions: These findings show that the transcription profiles from white and black horse skin provide useful information to understand the genetics underlying the control of skin melanin synthesis in horses, which may enhance our knowledge of human skin diseases, such as melanoma and albinism.
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