Integration of high-throughput omics technologies in medicinal plant research: The new era of natural drug discovery
文献类型： 外文期刊
作者： Zhang, Wenting 1 ; Zeng, Yuan 3 ; Jiao, Meng 5 ; Ye, Chanjuan 6 ; Li, Yanrong 5 ; Liu, Chuanguang 6 ; Wang, Jihua 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Crops Res Inst, Guangdong Prov Key Lab Crops Genet & Improvement, Guangzhou, Peoples R China
2.Guangdong Prov Engn & Technol Res Ctr Conservat &, Guangzhou, Peoples R China
3.Virginia Tech, Sch Plant & Environm Sci, Blacksburg, VA USA
4.Virginia Tech, Southern Piedmont Agr Res & Extens Ctr, Blackstone, VA USA
5.South China Agr Univ, Coll Life Sci, Guangzhou, Peoples R China
6.Guangdong Acad Agr Sci, Rice Res Inst, Guangdong Rice Engn Lab, Guangdong Key Lab New Technol Rice Breeding, Guangzhou, Peoples R China
关键词： medicinal plant; high-throughput omics; biosynthesis pathways; active ingredients; phytochemicals
期刊名称：FRONTIERS IN PLANT SCIENCE （ 影响因子：5.6； 五年影响因子：6.8 ）
ISSN： 1664-462X
年卷期： 2023 年 14 卷
页码：
收录情况： SCI
摘要： Medicinal plants are natural sources to unravel novel bioactive compounds to satisfy human pharmacological potentials. The world's demand for herbal medicines is increasing year by year; however, large-scale production of medicinal plants and their derivatives is still limited. The rapid development of modern technology has stimulated multi-omics research in medicinal plants, leading to a series of breakthroughs on key genes, metabolites, enzymes involved in biosynthesis and regulation of active compounds. Here, we summarize the latest research progress on the molecular intricacy of medicinal plants, including the comparison of genomics to demonstrate variation and evolution among species, the application of transcriptomics, proteomics and metabolomics to explore dynamic changes of molecular compounds, and the utilization of potential resources for natural drug discovery. These multi-omics research provide the theoretical basis for environmental adaptation of medicinal plants and allow us to understand the chemical diversity and composition of bioactive compounds. Many medicinal herbs' phytochemical constituents and their potential health benefits are not fully explored. Given their large diversity and global distribution as well as the impacts of growth duration and environmental factors on bioactive phytochemicals in medicinal plants, it is crucial to emphasize the research needs of using multi-omics technologies to address basic and applied problems in medicinal plants to aid in developing new and improved medicinal plant resources and discovering novel medicinal ingredients.
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