文献类型： 外文期刊

作者： Narita, M ¹ ; Zhao, YM ² ; Kawashima, K ² ; Arai, S ² ; Hirose, H ² ; Yamada, S ² ; Ezura, K ² ;

作者机构： 1.Natl Inst Anim Hlth, Tsukuba, Ibaraki 305, Japan

2.Natl Inst Anim Hlth, Tsukuba, Ibaraki 305, Japan; Jilin Acad Agr Sci, Gongzhuling 136100, Jilin, Peoples R China; Tochigi Livestock Sanit Lab, Utsunomia, Tochigi 320, Japan

期刊名称：JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION （ 影响因子：1.279； 五年影响因子：1.522 ）

ISSN： 1040-6387

年卷期： 1998 年 10 卷 1 期

页码：

收录情况： SCI

摘要： Three different strains of pseudorabies (Aujeszky's disease) virus were inoculated into ligated closed loops in the jejunum and ileum of five specific-pathogen-free pigs. Infected areas were compared with respect to distribution of histologic lesions and pseudorabies virus antigen. Two wild-type strains of pseudorabies virus produced enteric lesions consisting of necrosis of the subepithelial macrophages in the basilar crypt epithelium, necrosis of the lymphoid follicles in the Peyer's patches, degeneration of the epithelial cells in the crypt and villi, degeneration of the neuronal cells in the myenteric plexuses, and formation of intranuclear inclusion bodies on postinoculation days 2-4. Pseudorabies virus antigen was initially detected in subepithelial macrophages of the dome of Peyer's patches on postinoculation day 2 and subsequently extended to superficial epithelium and deeper into the lymphoid follicles and myenteric plexuses on postinoculation days 3-4. Many pseudorabies virus particles were also detected in the center of their necrotic foci. However, 1 mutant strain (ara-T-resistant) of pseudorabies virus did not produce enteric lesions. The results suggest that the primary target of infection by wild-type strains of pseudorabies virus might be the macrophages distributed in the subepithelial area of the dome Peyer's patches.