Synergistic effect of chitosan and β-carotene in inhibiting MNU-induced retinitis pigmentosa
文献类型： 外文期刊
作者： Shi, Enjuan 1 ; Wang, Xiaoqin 1 ; Jing, Huili 1 ; Xu, Yayuan 1 ; Feng, Lei 1 ; He, Fatao 2 ; Li, Dajing 1 ; Dai, Zhuqing 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China
2.All China Federat Supply & Mkt Cooperat, Jinan Fruit Res Inst, Jinan 250014, Peoples R China
3.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China
关键词： Chitosan; beta-Carotene; Retinitis pigmentosa; Gut microbiota
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）
ISSN： 0141-8130
年卷期： 2024 年 268 卷
页码：
收录情况： SCI
摘要： In this study, N -Methyl-N-nitrosourea (MNU) was intraperitoneally injected to construct a mouse retinitis pigmentosa (RP) model to evaluate the protective effect of chitosan and beta- carotene on RP. The results demonstrated that chitosan synergized with beta- carotene significantly reduced retinal histopathological structural damage in RP mice. The co-treatment group of beta- carotene and chitosan restored the retinal thickness and outer nuclear layer thickness better than the group treated with the two alone, and the thickness reached the normal level. The content of beta- carotene and retinoids in the liver of chitosan and beta- carotene co-treated group increased by 46.75 % and 20.69 %, respectively, compared to the beta- carotene group. Chitosan and beta- carotene supplement suppressed the expressions of Bax, Calpain2, Caspase3, NF- kappa B, TNF-alpha, IL-6, and IL-1 beta, and promoted the up-regulation of Bcl2. Chitosan and beta- carotene interventions remarkably contributed to the content of SCFAs and enhanced the abundance of Ruminococcaceae , Rikenellaceae , Odoribacteraceae and Helicobacteraceae . Correlation analysis demonstrated a strong association between gut microbiota and improvement in retinitis pigmentosa. This study will provide a reference for the study of the gut-eye axis.
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